Virilizing Adrenocortical Tumor: A Case Report

    May 2016 in “ Endocrine Abstracts ”
    Silvia Maraver-Selfa, Isabel Cornejo‐Pareja, Cristina Diaz-Perdigones, Isabel Mancha-Doblas, Francisco J. Tinahones
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    TLDR The removal of the adrenal tumor improved the patient's symptoms and reduced androgen levels, indicating successful surgery.
    In 2016, a case study was conducted on a 31-year-old woman who had a history of hirsutism, acne, and androgenetic alopecia, symptoms of SAHA syndrome. She had a right adrenal mass, which was removed through adrenalectomy. The mass was a 6.8 cm, 120 g lesion, diagnosed as a corticoadrenal adenoma. Post-surgery, the patient began hydrocortisone replacement therapy and showed improvement, including spontaneous menstruation and weight loss. Biochemical tests showed a significant reduction in androgen levels. The study concluded that distinguishing between benign and malignant adrenocortical tumors (ACT) is challenging, even with anatomo-pathology diagnosis. The best indicator of malignancy is clinical evolution, and in this case, the rapid reduction of androgens post-surgery indicated surgical success.
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