Steroid Inhibitors of Androgen-Potentiated Actions on Skin

    July 1983 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”
    F. J. Ebling, Valerie A. Randall
    TLDR Certain hormones can reduce skin oil and hair growth, potentially helping treat acne and excessive hair in women.
    The study investigated the effects of antiandrogens, such as cyproterone acetate, and estrogens on sebaceous secretion and their potential for treating hirsutism and acne. In castrated rats treated with testosterone, 3 μg/day of estradiol significantly reduced sebum secretion more than a much larger dose of cyproterone acetate. In hirsute women, 100 mg of cyproterone acetate daily reduced sebum secretion by 40% within 10 days, with an additional 20% reduction when combined with ethinyloestradiol. Hair growth reduction was observed after four months of treatment. The study suggested that these effects were mainly peripheral, with possible contributions from reduced plasma androgens and increased sex hormone-binding globulin. Local application of either compound also decreased sebum secretion in rats.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 120 results

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  123 upvotes 2 years ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

      community Switch from fin to dut and its worse

      in Finasteride/Dutasteride  6 upvotes 9 months ago
      Switching from finasteride to dutasteride can worsen hair loss for some men due to increased testosterone levels. Topical treatments like RU58841 and Pyrilutamide are suggested to counteract these effects, but individual responses vary.

      community So depressed and upset with how much progress I’ve lost

      in Chat  51 upvotes 2 years ago
      A 20-year-old started taking finasteride for hair loss at 18, saw improvement, but developed erectile dysfunction (ED) after taking accutane. Despite stopping both medications, ED persisted, and hair loss worsened. Advice given includes considering tadalafil for ED, resuming finasteride, using minoxidil, and addressing psychological factors through positive thinking and lifestyle changes.

      community Extreme regimen and still miniaturized hairs. AGA is just impossible to beat.

      in Insane  37 upvotes 3 years ago
      A user's extreme regimen for hair loss, which includes taking oral and topical medications such as minoxidil, dutasteride, cyproterone acetate and bicalutamide, but still experiencing miniaturization. Suggestions were made to try other treatments such as RU58841 and Pyrilutamide, while also considering mental health treatment and advice on lookmaxxing.

      community 5 months of nuking T, 2 months of minoxidil

      in Transgender  487 upvotes 1 year ago
      The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.

    Similar Research

    6 / 1000+ results
      Contraception And The Skin

      research Contraception And The Skin

      2 citations , August 1987 in “Australasian Journal of Dermatology”
      Birth control pills can cause skin issues but may help with acne and hirsutism, and choosing the right type can minimize side effects.
      Acne

      research Acne

      2 citations , May 2011 in “Harper's Textbook of Pediatric Dermatology”
      Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.
      Estrogens and the Skin

      research Estrogens and the Skin

      137 citations , June 2005 in “Climacteric”
      Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.
      Understanding Polycystic Ovary Syndrome

      research Understanding Polycystic Ovary Syndrome

      2 citations , September 2009 in “Nurse Prescribing”
      PCOS affects many women, causing various symptoms and health risks, and is managed through lifestyle changes, medication, and support groups.

      research Endocrine Intervention for Transsexuals

      88 citations , September 2003 in “Clinical endocrinology”
      Hormone treatment for transsexual individuals is effective but carries risks like thromboembolic events and mood changes, with most side effects being minor and reversible.
      Polycystic Ovary Syndrome: An Overview

      research Polycystic Ovary Syndrome: An Overview

      2 citations , March 2016 in “InnovAiT”
      PCOS is a common hormonal disorder in women, often involving menstrual issues and increased diabetes risk, managed through lifestyle changes and targeted treatments.