Steroid Inhibitors of Androgen-Potentiated Actions on Skin

    July 1983 in “ Journal of steroid biochemistry/Journal of Steroid Biochemistry ”
    F. J. Ebling, Valerie A. Randall
    TLDR Certain hormones can reduce skin oil and hair growth, potentially helping treat acne and excessive hair in women.
    The study investigated the effects of antiandrogens, such as cyproterone acetate, and estrogens on sebaceous secretion and their potential for treating hirsutism and acne. In castrated rats treated with testosterone, 3 μg/day of estradiol significantly reduced sebum secretion more than a much larger dose of cyproterone acetate. In hirsute women, 100 mg of cyproterone acetate daily reduced sebum secretion by 40% within 10 days, with an additional 20% reduction when combined with ethinyloestradiol. Hair growth reduction was observed after four months of treatment. The study suggested that these effects were mainly peripheral, with possible contributions from reduced plasma androgens and increased sex hormone-binding globulin. Local application of either compound also decreased sebum secretion in rats.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 81 results

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  123 upvotes 11 months ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

      community Extreme regimen and still miniaturized hairs. AGA is just impossible to beat.

      in Insane  35 upvotes 1 year ago
      A user's extreme regimen for hair loss, which includes taking oral and topical medications such as minoxidil, dutasteride, cyproterone acetate and bicalutamide, but still experiencing miniaturization. Suggestions were made to try other treatments such as RU58841 and Pyrilutamide, while also considering mental health treatment and advice on lookmaxxing.

      community 5 months of nuking T, 2 months of minoxidil

      in Transgender  485 upvotes 2 months ago
      The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.

      community Insane MTF recovery 18 months blocking androgens

      in Progress Pictures  145 upvotes 1 year ago
      Hair loss recovery using estrogen and anti-androgen treatment for 18 months showed significant improvement. However, results vary and alternative treatments like RU58841 and Dutasteride may work without systemic feminization.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

    Similar Research

    5 / 1000+ results
      Contraception And The Skin

      research Contraception And The Skin

      2 citations, August 1987 in “Australasian Journal of Dermatology”
      Birth control pills can cause skin issues but may help with acne and hirsutism, and choosing the right type can minimize side effects.
      Acne

      research Acne

      2 citations, May 2011 in “Harper's Textbook of Pediatric Dermatology”
      Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.