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    Did you mean T cell receptor signaling?
    Glossary T cell receptor signaling

    process where T cells recognize and respond to antigens

    T cell receptor signaling, often abbreviated as TCR signaling, is a crucial process in the immune system where T cells recognize and respond to foreign molecules, such as pathogens. When a T cell receptor binds to an antigen presented by other cells, it triggers a cascade of intracellular events that activate the T cell, enabling it to attack infected cells or coordinate other parts of the immune response. This signaling is essential for the body's ability to detect and fight infections and diseases.

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    1. 020 Sphingosine 1-phosphate receptor signalling promotes hair growth and inhibits perifollicular T-cell expansion and immune privilege collapse ex vivo Journal of Investigative Dermatology · 2021 · 1 citations
    2. TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia Cell Death and Disease · 2016 · 38 citations
    3. BI02 (P97): Epidermal growth factor receptor inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of immune privilege British Journal of Dermatology · 2022
    4. Ku80 as a Novel Receptor for Thymosin β4 That Mediates Its Intracellular Activity Different from G-actin Sequestering Journal of Biological Chemistry · 2007 · 37 citations
    5. Essential Role of STAT3 Signaling in Hair Follicle Homeostasis Frontiers in immunology · 2021 · 6 citations
    6. TYK2 Inhibition with Deucravacitinib Improves Clinical Outcomes and Resolves Interferon-Driven Inflammation in Lichen Planopilaris 2026
    7. Mendelian randomization study highlights hypothyroidism as a causal determinant of alopecia areata Frontiers in endocrinology · 2024
    8. Multiplex matrix network analysis of protein complexes in the human TCR signalosome Science Signaling · 2016 · 32 citations
    9. Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia Research Square (Research Square) · 2023
    10. Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata BBA clinical · 2016 · 12 citations
    11. Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege bioRxiv (Cold Spring Harbor Laboratory) · 2023
    12. Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation BioMed Research International · 2019 · 4 citations
    13. Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation bioRxiv (Cold Spring Harbor Laboratory) · 2023
    14. Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations Frontiers in immunology · 2022 · 21 citations
    15. Regulatory T cell dysfunction and immunotherapeutic breakthroughs in type 1 diabetes Frontiers in Endocrinology · 2026 · 2 citations
    16. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019 · 181 citations
    17. Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration Cell Reports · 2025
    18. JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia EMBO Molecular Medicine · 2024 · 8 citations
    19. Down-RANKing the Threat of HSV-1: RANKL Upregulates MHC-Class-I-Restricted Anti-Viral Immunity in Herpes Simplex Virus Infection Journal of Investigative Dermatology · 2015 · 2 citations
    20. 056 IL-15 prolongs hair growth and operates as a guardian of human hair follicle immune privilege Journal of Investigative Dermatology · 2022
    21. Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling PloS one · 2014 · 56 citations
    22. The JAK/STAT signaling pathway: from bench to clinic Signal Transduction and Targeted Therapy · 2021 · 489 citations
    23. The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances Frontiers in Immunology · 2025 · 4 citations
    24. Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle Experimental Dermatology · 2021 · 14 citations
    25. Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding Seminars in Cell & Developmental Biology · 2019 · 28 citations
    26. LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes Journal of Investigative Dermatology · 2023
    27. [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs Biochemical Pharmacology · 2007 · 26 citations
    28. High-throughput T cell receptor sequencing identifies clonally expanded CD8+ T cell populations in alopecia areata JCI insight · 2018 · 46 citations
    29. Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation Genes & Development · 2014 · 40 citations
    30. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations