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Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

Finasteride doesn't affect ovulation in normal women.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

A topical treatment safely and effectively reduced acne by causing targeted cell death in sebaceous glands without side effects.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Finasteride safely lowers DHT levels without affecting testosterone.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Finasteride effectively lowers specific hormone levels, helping monitor treatment progress.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

New genes and pathways are important for testosterone production and male sexual development.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Testosterone is crucial for development, growth, and various body functions in mammals.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

Gene mutations can cause problems in male genital development.

A certain mutation in the fetal alpha 5-reductase gene is linked to a higher risk of late miscarriage.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

Finasteride helps induce ovulation in nonresponder PCOS women.

Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.

Father's finasteride use may affect son's fertility and testicular function.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Finasteride caused long-term sexual and non-sexual side effects in young men with hair loss.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.