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    Did you mean Steroid Sulfatase Inhibitors?
    Glossary Steroid Sulfatase Inhibitors

    block enzyme activity to reduce active steroid levels

    Steroid Sulfatase Inhibitors (STS inhibitors) are compounds that block the activity of the enzyme steroid sulfatase, which is involved in the conversion of sulfated steroid precursors into active steroids like estrogen. By inhibiting this enzyme, STS inhibitors can reduce the levels of active steroids, potentially offering therapeutic benefits in conditions like hormone-sensitive cancers and certain skin disorders.

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    Research 30 of 1000+

    1. Sulfatase inhibitors: a patent review Expert Opinion on Therapeutic Patents · 2012 · 47 citations
    2. 2-Substituted 4-(Thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2002 · 111 citations
    3. Steroid sulfatase inhibitors Medicinal Research Reviews · 2004 · 108 citations
    4. Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2003 · 37 citations
    5. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 25 citations
    6. N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase Bioorganic & Medicinal Chemistry Letters · 2004 · 17 citations
    7. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 1 citations
    8. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001 · 61 citations
    9. Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination Current Opinion in Chemical Biology · 2008 · 83 citations
    10. Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition Endocrine Reviews · 2005 · 451 citations
    11. Minoxidil Sulfate Regulates JAK / STAT Signalling and Mitochondrial Function in Alopecia Areata Experimental Dermatology · 2026
    12. Plasma androsterone/epiandrosterone sulfates as markers of 5α-reductase activity: Effect of finasteride in normal men Steroids · 1997 · 13 citations
    13. Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May Be Mediated by Dehydroepiandrosterone. Letter. The Journal of Urology · 2022 · 1 citations
    14. The 5α-reductase inhibitor finasteride reduces opioid self-administration bioRxiv (Cold Spring Harbor Laboratory) · 2020
    15. Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth Skin pharmacology and physiology · 2000 · 32 citations
    16. Oral zinc sulphate causes murine hair hypopigmentation and is a potent inhibitor of eumelanogenesis<i>in vivo</i> 2006 · 30 citations
    17. Targets to treat androgen excess in polycystic ovary syndrome Expert Opinion on Therapeutic Targets · 2015 · 14 citations
    18. Investigational medications in the treatment of alopecia Expert Opinion on Investigational Drugs · 2005 · 3 citations
    19. An update on the treatment of female alopecia and the introduction of a potential novel therapy Clinical and Experimental Obstetrics & Gynecology · 2015 · 3 citations
    20. Unraveling the Complex: Changes in Secondary Science Preservice Teachers' Assessment Expertise ProQuest LLC eBooks · 2012
    21. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    22. Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency. PubMed · 1995 · 74 citations
    23. The Hormonal Background of Hair Loss in Non-Scarring Alopecias Biomedicines · 2024
    24. Characterization of recombinant human liver dehydroepiandrosterone sulfotransferase with minoxidil as the substrate Biochemical Pharmacology · 1997 · 13 citations
    25. Antizyme Release Is an Early Event in Ornithine Decarboxylase Induction by Hair Plucking Journal of Investigative Dermatology · 1983 · 3 citations
    26. A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer Current Medicinal Chemistry · 2008 · 431 citations
    27. Simultaneous determination of minoxidil and minoxidil sulfate by high-performance liquid chromatography with UV-detection and its applications Medicine in Drug Discovery · 2020 · 4 citations
    28. Dual inhibitors of urease and carbonic anhydrase-II from <i>Iris</i> species Pure and Applied Chemistry · 2019 · 8 citations
    29. Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review Dermatology and Therapy · 2026
    30. Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010 · 223 citations