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Both drugs lower DHT levels, with GI198745 being more effective.

Spironolactone can reduce hair growth in women with hirsutism.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Nitric oxide gel helps heal skin burns faster by improving skin growth, hair regrowth, and blood vessel formation.

Cyclosporin is effective for treating skin conditions in small animals, but requires careful dosing and monitoring for side effects.

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.

K16 can partially replace K14 but causes hair loss and skin issues.

Chitosan-decorated polymersomes improve finasteride delivery for hair loss treatment.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Non-binary transgender individuals need personalized hormonal treatments for better well-being and quality of life.

Artificial sebum L closely mimics human sebum for drug delivery research.

Spironolactone helps reduce pain and lesions in hidradenitis suppurativa patients, and lower doses are also effective.

Finasteride-loaded nanoparticles may help treat alopecia.

Improved hair loss treatment using special particles and surfactants.

Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.

Surface-modified nanoparticles mainly use non-follicular pathways to enhance skin permeation of ibuprofen and could improve treatment for inflammatory skin diseases.

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Dutasteride effectively treats enlarged prostate, reduces prostate cancer risk, and promotes hair regrowth with few side effects.

Androgen hormones cause hair follicle scarring in hair loss, and finasteride helps reduce it.

Lipophilic dyes accumulate more in hair follicles when delivered with surfactant-propylene glycol solutions.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

Minoxidil's effectiveness decreases as vehicle evaporates; concentration and thermodynamic activity matter.

Special immune cells called Regulatory T cells help control skin inflammation and repair in various skin diseases.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.