Cyclosporin: Applications in Small Animal Dermatology

The 2003 document reviewed the use of Cyclosporin (CyA) for treating various skin conditions in small animals, highlighting its effectiveness in diseases like atopic dermatitis in dogs and feline acquired alopecia, among others. It detailed the dosages, side effects, and the importance of monitoring serum concentrations of CyA. Studies mentioned include one with 16 dogs showing a 93% resolution rate for perianal fistulae after 16 weeks of CyA and ketoconazole treatment, and another with 20 German Shepherd dogs showing an 85% healing rate for sebaceous adenitis after 16 weeks. Side effects were generally minor, with gastrointestinal issues being the most common. The document stressed the need for further research to confirm CyA's efficacy and recommended regular monitoring of blood counts, biochemistries, and blood pressure due to potential adverse reactions, especially in cats where diarrhea was frequently observed at higher CyA trough concentrations. The optimal dosing rates and the relationship between blood CyA concentrations and dermatologic disease treatment were not well defined, indicating a need for further study in these areas.