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A specific molecular switch, driven by MAPK/ERK signaling, helps spiny mice heal wounds by regenerating skin instead of forming scars.

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.

Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

Spiny mice are better at regenerating hair after injury than laboratory mice and could help us understand how to improve human skin repair.

Spiny mice regenerate skin better than laboratory mice due to larger hair bulges, more stem cells, and different collagen ratios.

The spiny mouse can regenerate its skin without scarring, which could help us learn how to heal human skin better.

Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.

Bacteria can help skin regenerate through a process called IL-1β signaling.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

The spiny mouse is a unique menstruating rodent that can help us understand menstruation and reproductive disorders.

The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.

The spiny mouse regenerates ear tissue asymmetrically, with gene expression differences possibly explaining its unique healing abilities.

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

The African spiny mouse can fully regenerate its muscle without scarring, unlike the common house mouse.

Mice can regrow hair on wounds due to specific cell interactions and mechanical forces not seen in rats.

Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.

New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.

Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.

Some wound-healing cells can turn into fat cells around new hair growth in mice.

Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.

Careful selection of mice by genetics and age, and controlled housing conditions improve the reliability of hair regrowth in wound healing tests.

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

Certain cells in the adult mouse ear come from cranial neural crest cells, but muscle and hair cells do not.

Rats can't grow new hair follicles after skin wounds, unlike mice, due to differences in gene expression and response to WNT signaling.

Using rodents for research shows that health problems in the womb can cause diseases later in life.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

The symposium concluded that understanding how different species repair tissue and how this changes with age can help advance regenerative medicine.