Spatial Transcriptomics Reveals Asymmetric Cellular Responses to Injury in the Regenerating Spiny Mouse Ear

    August 2023 in “ Genome research ”
    Henriëtte van Beijnum, Tim Koopmans, Antonio Tomasso … Kerstin Bartscherer
    Studysummary This study found that in spiny mice, the proximal side of ear wounds is crucial for regeneration, a process possibly linked to unique injury-induced immune responses compared to nonregenerative rodents.
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    Research cited in this study 6

    1. An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice Science Advances · 2023
    2. Adult Spiny Mice (Acomys) Exhibit Endogenous Cardiac Recovery in Response to Myocardial Infarction npj Regenerative Medicine · 2021
    3. Scars Or Regeneration? Dermal Fibroblasts As Drivers Of Diverse Skin Wound Responses International Journal of Molecular Sciences · 2020
    4. The Blastema and Epimorphic Regeneration in Mammals Developmental Biology · 2017
    5. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012
    6. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000