An ERK-Dependent Molecular Switch Antagonizes Fibrosis And Promotes Regeneration In Spiny Mice (Acomys)

    June 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Antonio Tomasso, Kerstin Bartscherer, Ashley W. Seifert

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that MAPK/ERK signaling plays a key role in driving tissue regeneration in spiny mice and suggests potential for reversing fibrosis to promote regeneration in mammals.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 4

    1. The Blastema and Epimorphic Regeneration in Mammals Developmental Biology · 2017
    2. Concise Review: Translating Regenerative Biology Into Clinically Relevant Therapies: Are We on the Right Path? Stem Cells Translational Medicine · 2017
    3. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    4. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012

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