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This study found that freeze-dried finasteride nanoparticles significantly improved the dissolution rate and pharmacokinetic parameters compared to pure drug formulations, suggesting enhanced stability and solubility for poorly water-soluble drugs.

This review discusses technological advances in liposome systems for drug delivery and reports no new clinical results; it highlights the clinical acceptance and market presence of liposomal products.

This review reports on the current state and potential of solid lipid nanoparticles for drug delivery, emphasizing their safety, biocompatibility, and ease of production, and highlights challenges in translating them to clinical practice, including active clinical trials.

This research reported that squarticles, nanoparticles made from sebum-derived lipids, enhanced the follicular delivery and skin accumulation of diphencyprone and minoxidil, indicating effective drug deposition with reduced systemic absorption in alopecia treatment.

This study suggests that novel lipid nanoparticle formulations may be suitable for delivering anti-alopecia compounds like minoxidil and finasteride, although their skin penetration was limited.

This study developed nanostructured lipid carriers for finasteride that demonstrated high encapsulation efficiency and reduced cytotoxicity, suggesting potential as a topical treatment for androgenetic alopecia.

This review highlights recent advancements in lipid nanoparticle technology for delivering genetic material and treating various diseases, but notes challenges in manufacturing, stability, and safety evaluations.

This study suggests that polymersomes decorated with chitosan improve the transdermal delivery of finasteride, providing an alternative drug delivery system with higher drug retention in the skin.

This study found that Sol/ASC-DP nanoparticles could enhance the skin permeability of minoxidil due to improved stability and hydrophobic interactions in the nanoparticle structure.

This study found that the spermidine analog N1-methylspermidine prolonged hair follicle growth and decreased inflammation and oxidative stress in cultured hair follicles, suggesting potential relevance for treating inflammatory scalp diseases.

This study found that sub-100 nm solid lipid nanoparticles showed the most effective skin penetration and depth, primarily via hair follicles, in rat skin evaluations.

In this study, researchers developed a new method for producing dissolving microneedle array patches containing mesoporous silica nanoparticles, successfully confirming nanoparticle deposition and release in both ex vivo and in vivo models.

This study describes a capillary GC method for accurately measuring spermidine levels in hair lotions, confirming its precision and specificity for this application.

Liposomes improve minoxidil delivery to hair follicles, enhancing treatment for hair loss.

PMS nanoparticles improve damaged hair by protecting and restoring its surface and color.

This study found that using hollow mesoporous silica nanoparticles as carriers in a topical finasteride formulation significantly enhanced drug retention and hair regrowth in an AGA mouse model, suggesting a promising approach for treating androgenetic alopecia with reduced side effects.

This study found that freeze-dried finasteride nanoparticles improved the stability, solubility, and in vitro dissolution of the drug, indicating potential benefits for poorly water-soluble drugs.

This study demonstrated that minoxidil-encapsulated PLLGA nanoparticles significantly increased minoxidil delivery to hair follicles compared to a minoxidil aqueous solution in mice.

This research found that liquid-state liposomes and niosomes may enhance finasteride delivery to pilosebaceous units in hamsters more effectively than gel-state vesicles or hydroalcoholic solution.

This study found that Soluplus and L-ascorbyl 2,6-dipalmitate nanoparticles may improve minoxidil's skin permeability through stable hydrophobic interactions, enhancing its potential for targeted skin application.

This study found that administering spermidine to aged mice for six months significantly reduced various age-related conditions, including brain, heart, kidney, liver issues, and hair loss, possibly due to decreased telomere attrition.

In this study, topical application of α-methylspermidine during the telogen phase in mice induced hair growth by increasing the polyamine pool and mimicking the anagen phase's characteristics.

This study demonstrated that liquid-state vesicles may reduce the absorption of finasteride through the skin while increasing its concentration and retention in the dermis layer in hamster models.

This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.

In this study, researchers developed a novel gel formulation combining zinc oxide nanoparticles and finasteride-loaded nanostructured lipid carriers, which showed promising results for topical delivery and effective skin penetration, potentially offering a new treatment approach for androgenic alopecia.

This study found that a topical formulation with nanostructured lipid carriers containing finasteride significantly restored hair follicles in androgenetic alopecia-induced rats without systemic absorption, suggesting its potential for safer and effective AGA treatment.

This study developed a new finasteride release system using chitosan-based nanoniosomes, observing that 70% of the drug was released over ten days in vitro, suggesting potential for prostate cancer prevention.

This study found that preparing Finasteride micro and nanoparticles using a gas-antisolvent method reduced the particle size significantly.

This study reports that combining low level laser treatment with liposome-delivered methylene blue may effectively target sebaceous glands in mice, with efficacy influenced by laser timing and drug absorption.

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.