Study of Thin Films and Nanoparticles Obtained by Self-Assembly of Block Copolymers and Their Interactions with an Oligo/Polysaccharide
April 2011
in “
HAL (Le Centre pour la Communication Scientifique Directe)
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study suggests that polymersomes decorated with chitosan improve the transdermal delivery of finasteride, providing an alternative drug delivery system with higher drug retention in the skin. Our plain-language summary of this paper — not a Tressless recommendation.
This study investigated the self-assembly of block copolymers to form thin films and nanoparticles, focusing on their interactions with chitosan, a polysaccharide. The research explored the potential of these systems for transdermal drug delivery, specifically for finasteride, a treatment for androgenetic alopecia. The study found that nanoparticles decorated with chitosan improved the skin permeation of finasteride, with the PS404-b-PAA63 polymersome system showing the most promise due to higher drug retention and lower permeation flux. This suggests that the PS-b-PAA/chitosan system could be an effective alternative for delivering finasteride transdermally.
