Study of Thin Films and Nanoparticles Obtained by Self-Assembly of Block Copolymers and Their Interactions with an Oligo/Polysaccharide

April 2011 in “ HAL (Le Centre pour la Communication Scientifique Directe) ”

Ledilege Cucco Porto

finasteride androgenetic alopecia chitosan transdermal drug delivery PS404-b-PAA63 block copolymers nanoparticles thin films polysaccharide Propecia

TLDR Chitosan-decorated nanoparticles improve skin delivery of finasteride, with PS404-b-PAA63 being most effective.

This study investigated the self-assembly of block copolymers to form thin films and nanoparticles, focusing on their interactions with chitosan, a polysaccharide. The research explored the potential of these systems for transdermal drug delivery, specifically for finasteride, a treatment for androgenetic alopecia. The study found that nanoparticles decorated with chitosan improved the skin permeation of finasteride, with the PS404-b-PAA63 polymersome system showing the most promise due to higher drug retention and lower permeation flux. This suggests that the PS-b-PAA/chitosan system could be an effective alternative for delivering finasteride transdermally.

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