The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

The study investigated the impact of particle size on the deposition of solid lipid nanoparticles (SLNs) in different skin layers. SLNs of varying sizes (80, 333, and 971 nm) were prepared and applied to rat skin, with their penetration monitored using fluorescence microscopy. Results indicated that smaller SLNs, particularly those under 100 nm, demonstrated superior penetration depth and rate, primarily through hair follicles. This suggested that selecting the appropriate particle size could significantly influence the effectiveness of dermal drug delivery.