The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

    March 2016 in “ PubMed
    Zahra Mardhiah Adib, Saeed Ghanbarzadeh, Maryam Kouhsoltani, Ahmad Yari Khosroshahi, Hamed Hamishehkar
    TLDR Smaller particles improve drug delivery through the skin.
    The study investigated how the size of solid lipid nanoparticles affected their deposition in various skin layers, which in turn influenced the effectiveness of dermal drug delivery. The findings suggested that choosing the right particle size was crucial for optimizing therapeutic outcomes in skin treatments. This research highlighted the importance of particle size in enhancing the delivery and efficacy of drugs administered through the skin.
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