The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

March 2016 in “ PubMed ”

Zahra Mardhiah Adib, Saeed Ghanbarzadeh, Maryam Kouhsoltani, Ahmad Yari Khosroshahi, Hamed Hamishehkar

solid lipid nanoparticles dermal drug delivery skin layers therapeutic outcomes drug delivery

Studysummary This study found that sub-100 nm solid lipid nanoparticles showed the most effective skin penetration and depth, primarily via hair follicles, in rat skin evaluations. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the impact of particle size on the deposition of solid lipid nanoparticles (SLNs) in different skin layers. SLNs of varying sizes (80, 333, and 971 nm) were prepared and applied to rat skin, with their penetration monitored using fluorescence microscopy. Results indicated that smaller SLNs, particularly those under 100 nm, demonstrated superior penetration depth and rate, primarily through hair follicles. This suggested that selecting the appropriate particle size could significantly influence the effectiveness of dermal drug delivery.

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Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia

research Histological Assessment of Follicular Delivery of Flutamide by Solid Lipid Nanoparticles: Potential Tool for the Treatment of Androgenic Alopecia

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This study concluded that Flutamide-loaded solid lipid nanoparticles may enhance hair follicle drug delivery and promote hair growth in androgenic alopecia compared to a Flutamide hydroalcoholic solution.

research Delivery and Targeting of Nanoparticles into Hair Follicles

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research Selective Follicular Targeting by Modification of the Particle Sizes

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This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.

research Follicular Penetration of Topically Applied Caffeine via a Shampoo Formulation

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In this study, caffeine applied in a shampoo penetrated hair follicles faster and more effectively than through the skin surface within the first 20 minutes.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study introduces a novel non-invasive method called "differential stripping" to quantify the penetration of topically applied substances into hair follicles.

research Dermal Delivery of Topically Applied Oligonucleotides via Follicular Transport in Mouse Skin

64 citations , April 2005 in “Journal of Investigative Dermatology”

This study observed that topical oligonucleotide penetration in mouse skin involves a follicular route, suggesting potential suitability for targeting hair follicle-related structures.