Novel Aspects of Age-Protection by Spermidine Supplementation Are Associated with Preserved Telomere Length

January 2021 in “ GeroScience ”

Alexander Wirth, Bettina Wolf, Cheng-Kai Huang, Silke Glage, Sebastian J. Hofer, Marion Bankstahl, Christian Bär, Thomas Thum, Kai G. Kahl, Stephan J. Sigrist, Frank Madeo, Jens P. Bankstahl, Evgeni Ponimaskin

spermidine telomere attrition age-induced hair loss

Studysummary This study found that administering spermidine to aged mice for six months significantly reduced various age-related conditions, including brain, heart, kidney, liver issues, and hair loss, possibly due to decreased telomere attrition.

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A 6-month administration of spermidine in drinking water to aged mice significantly attenuated various age-associated phenotypes, including brain glucose metabolism modulation, suppression of cardiac inflammation, reduction of pathological sites in kidney and liver, and decreased age-induced hair loss. The study suggested that spermidine's age-protective effects were linked to decreased telomere attrition, indicating a novel cellular mechanism behind its anti-ageing properties.

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