Novel Aspects of Age-Protection by Spermidine Supplementation Are Associated with Preserved Telomere Length

A 6-month administration of spermidine in drinking water to aged mice significantly attenuated various age-associated phenotypes, including brain glucose metabolism modulation, suppression of cardiac inflammation, reduction of pathological sites in kidney and liver, and decreased age-induced hair loss. The study suggested that spermidine's age-protective effects were linked to decreased telomere attrition, indicating a novel cellular mechanism behind its anti-ageing properties.