TLDR Spermidine helps protect against aging by preserving telomere length.
A 6-month administration of spermidine in drinking water to aged mice significantly attenuated various age-associated phenotypes, including brain glucose metabolism modulation, suppression of cardiac inflammation, reduction of pathological sites in kidney and liver, and decreased age-induced hair loss. The study suggested that spermidine's age-protective effects were linked to decreased telomere attrition, indicating a novel cellular mechanism behind its anti-ageing properties.
88 citations,
June 2019 in “Cell reports” Certain small molecules can promote hair growth by activating a cellular cleanup process called autophagy.
42 citations,
March 2018 in “PLOS Biology” Autophagy is important for human hair growth and health.
8 citations,
October 2017 in “Dermatology practical & conceptual” A spermidine-based supplement may help hair grow longer by keeping it in the growth phase.
81 citations,
February 2016 in “Veterinary pathology” Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.
51 citations,
September 2015 in “Medical Clinics of North America” The conclusion is that acne, alopecia, and hyperhidrosis are common skin issues with various treatments available, and accurate diagnosis is key for effective management.
61 citations,
July 2011 in “PLOS ONE” Spermidine may help reduce hair loss and deserves further testing as a treatment.
1 citations,
September 2023 in “Stem cell research & therapy” Mesenchymal stem cells could help treat aging-related diseases better than current methods.
36 citations,
August 2011 in “Journal of Controlled Release” Genetically-altered adult stem cells can help in wound healing and are becoming crucial in regenerative medicine and drug design.
1 citations,
September 2013 in “Elsevier eBooks” Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.
September 2013 in “Molecular Biology” The document suggests that activating autophagy might help with regeneration by removing old and damaged cells.
305 citations,
March 2008 in “AJP Endocrinology and Metabolism”
