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This study identified a new S100 fused-type protein, scaffoldin, in reptiles and birds and suggests that SFTP-positive epithelia serve as scaffolds for the growth of various skin appendages, indicating a common evolutionary origin.

In this study, researchers identified slow cycling label retaining cells in nail and sweat gland appendages, showing stem cell characteristics similar to hair follicles but with distinct features.

This study identified genes potentially involved in the development and differentiation of skin appendages in Atelerix albiventris, noting significant enrichment of immune-related genes in hair-type tissues.

This study found that monoclonal antibodies identified distinct staining patterns in benign and malignant skin appendage tumors, highlighting their potential as markers for analyzing skin tumors.

This study found that their novel 3D-imaging method, ASAXA-μCT, identified shrinkage of sweat glands as a key factor in skin aging, which leads to dermal defects, decreased elasticity, and increased wrinkling and sagging.

This study found that manipulating Wnt/β-catenin signaling in embryonic mammary glands impacted their development, with high activity levels hindering branching and potentially redirecting cells toward hair follicle identity instead of mammary tissue.

In this mouse study, the absence of the Ascl4 gene did not affect the development of hair follicles, teeth, or mammary glands, suggesting it is non-essential for these processes.

This study identified that pediatric transplant recipients experience specific skin changes related to medication use, with unique conditions like ichthyosiform xerosis in kidney recipients and skin scaling with pellagroid appearance in bone marrow recipients.

This study identified two novel genes, pmg-1 and pmg-2, expressed in various skin and gland tissues and potentially involved in the differentiation of epithelial cells in epidermal appendages.

This review summarizes the role of Ectodysplasin A signaling in skin appendage development and various diseases, noting potential clinical applications but reporting no new research findings.

This review explores the regenerative potential of hair follicles and their role in complete skin regeneration, emphasizing the influence of mechanical factors and niche signaling pathways on hair growth and loss.

In this review, researchers examined the molecular diversity and expression patterns of major skin appendage proteins, like keratins and EDC proteins, in tetrapods, highlighting recent findings in reptiles and birds and identifying knowledge gaps for future research.

This study used integrated single-cell chromatin and transcriptomic analyses in developing mouse skin to uncover gene networks involved in skin lineage specification and identified Mef2c+ upper fibroblasts as potential precursors to certain muscle-like structures, with cross-species findings in human skin.

This study found that Eda and activin A regulate Foxi3 expression, which may contribute to the development of hypohidrotic ectodermal dysplasia by affecting Foxi3 activity in ectodermal appendages like hair and teeth.

This review explores the impact of COVID-19 on skin appendages beyond COVID-toes, highlighting hair and nail disorders in affected individuals, but provides no new clinical results.

This study found that hair-type tissues in hedgehogs show higher enrichment of immune-related genes compared to spine-type tissues, suggesting that spines evolved to protect against injuries and infections.

The researchers reported that scaffoldin, a protein identified in chicken embryos, likely plays a role in forming periderm granules and contributes to the soft cornification of embryonic epidermis.

The study found that exposing Arbas Cashmere goats to a short photoperiod significantly increased cashmere production by extending the anagen phase of hair follicles, with gene expression changes identified as contributing factors.

This review explores how epidermal stem cells contribute to the development and maintenance of various skin structures, and highlights specific markers and proteins associated with these cells, but reports no new clinical results.

This study found that rete ridge morphogenesis in mammalian skin is directed by a BMP-dependent developmental program, which is evolutionarily distinct from other known pathways controlling the development of hair follicles, sweat glands, and fingerprint ridges.

In this study, researchers used transcriptomics and modeling to uncover previously unknown cell populations and marker genes in developing hair follicles, providing insights into early cell fate establishment and offering tools for further research on skin appendages.

This study identifies key transcriptomic features and a necessary dermal niche for eccrine gland development, advancing potential regenerative approaches for these vital skin appendages.

This study reveals that β-catenin and retinoic acid are key regulators in the gene networks controlling the fate of skin appendages, such as scales and feathers.

This study found that sweat gland stem cells primarily maintain sweat gland homeostasis but can trans-differentiate to aid in epidermal healing and regenerate diverse skin structures under certain conditions.

This study found that extracellular factors from a specific developmental stage can promote hair follicle neogenesis in adult skin by facilitating interactions between fibroblasts and keratinocytes.

This study identifies specific localization patterns of androgen, estrogen, and progesterone receptors in human skin, which could be crucial for understanding their roles in skin biology and pathology.

This study found that ATP synthases and the mitochondrial gene COX2 play a key role in determining the size of skin appendages in hedgehogs and mice by influencing energy metabolism and cell proliferation.

In this study, researchers mapped gene expression in developing hair follicles to reveal unknown cell populations and markers, suggesting early establishment of cell fates in hair placodes.

This review discusses the shared molecular and cellular processes in the early development stages of skin appendages like hair follicles, teeth, and mammary glands, reporting no new results.

This review discusses the role of activin signaling in hair follicle formation, hair growth cycling, and skin healing, but presents no new clinical findings.