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    Did you mean Severe Combined Immunodeficient Mice?
    Glossary Severe Combined Immunodeficient Mice

    laboratory mice with a genetic mutation causing a nonfunctional immune system

    Severe Combined Immunodeficient (SCID) mice are laboratory mice that lack a functional immune system due to a genetic mutation. This makes them highly valuable in scientific research, particularly for studying human diseases, testing new drugs, and conducting cancer research, as they can accept human cells and tissues without rejecting them.

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    1. Histologic and Cell Kinetic Studies of Hair Loss and Subsequent Recovery Process of Human Scalp Hair Follicles Grafted onto Severe Combined Immunodeficient Mice Journal of Investigative Dermatology · 2000 · 31 citations
    2. 080 Mouse models of alopecia areata: C3H/HeJ mice versus the humanized AA mouse model Journal of Investigative Dermatology · 2019
    3. T Cell Immunodeficiency, Congenital Alopecia, and Nail Dystrophy 2022
    4. A New Humanized Mouse Model for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013 · 25 citations
    5. FOXN1 deficient nude severe combined immunodeficiency Orphanet journal of rare diseases · 2017 · 32 citations
    6. Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations Journal of Clinical Immunology · 2021 · 30 citations
    7. Histologic Study of the Regeneration Process of Human Hair Follicles Grafted onto SCID Mice after Bulb Amputation Journal of Investigative Dermatology Symposium Proceedings · 2001 · 19 citations
    8. MOUSE MODELS FOR THE STUDY OF HUMAN HAIR LOSS Dermatologic Clinics · 1996 · 36 citations
    9. Human ClinicalPhenotype Associated with FOXN1 Mutations Advances in experimental medicine and biology · 2009 · 22 citations
    10. Sebaceous Gland Regeneration in Human Skin Xenografts Journal of Investigative Dermatology · 2010 · 9 citations
    11. Tissue engineering of human hair follicles using a biomimetic developmental approach Nature Communications · 2018 · 184 citations
    12. Epimorphic regeneration in mice is p53-independent Cell Cycle · 2010 · 20 citations
    13. Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis American journal of human genetics · 2019 · 53 citations
    14. Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2 Frontiers in immunology · 2019 · 98 citations
    15. Mite Burden and Immunophenotypic Response to <i>Demodex musculi</i> in Swiss Webster, BALB/c, C57BL/6, and NSG Mice Comparative medicine · 2020
    16. Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3 Cellular immunology · 2015 · 8 citations
    17. Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels Nature Communications · 2019 · 40 citations
    18. Cutaneous signals of immune system disease Current problems in dermatology · 1991
    19. Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts Laboratory Investigation · 2006 · 27 citations
    20. The potential of nestin-expressing hair follicle stem cells in regenerative medicine Expert Opinion on Biological Therapy · 2007 · 50 citations
    21. PKC downregulation upon rapamycin treatment attenuates mitochondrial disease Nature metabolism · 2020 · 26 citations
    22. Reconstitution of full-thickness skin by microcolumn grafting Journal of Tissue Engineering and Regenerative Medicine · 2016 · 38 citations
    23. Oral Combination Treatment of Gefitinib (IressaTM) and Sasam-Kyeongokgo: Synergistic Effects on the NCI-H520 Tumor Cell Line Applied sciences · 2023
    24. Multipotent nestin‐expressing hair follicle stem cells The Journal of Dermatology · 2009 · 37 citations
    25. FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program Frontiers in Immunology · 2013 · 69 citations
    26. Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression Veterinary Pathology · 1997 · 69 citations
    27. A Novel In Vivo Active Pemphigus Model Targeting Desmoglein1 and Desmoglein3: A Tool Representing All Pemphigus Variants Biology · 2023 · 2 citations
    28. Small molecules facilitate single factor-mediated sweat gland cell reprogramming Military Medical Research · 2022 · 9 citations
    29. Foxn1 in Skin Development, Homeostasis and Wound Healing International Journal of Molecular Sciences · 2018 · 21 citations
    30. A Clinical Approach to Severe Insulin Resistance KARGER eBooks · 2007 · 32 citations