19 citations
,
November 2012 in “Journal of Dermatological Treatment” In this study, isotretinoin treatment in women with severe acne increased body weight and triglycerides but did not affect androgens or insulin sensitivity.
13 citations
,
March 2014 in “Cutaneous and Ocular Toxicology” This study found that while isotretinoin lowered levels of female hormones in patients with severe acne, it did not significantly impact ovarian reserve function.
10 citations
,
March 2021 in “Clinical Cosmetic and Investigational Dermatology” This study found that specific genetic variants in the CYP21A2 and CYP19A1 genes were associated with severe acne vulgaris among Han Chinese, particularly in male patients.
September 2021 in “International Journal of Biomedicine” This study found that SNPs in the MVK, ARPC1B, and CA2 genes may indicate a genetic predisposition for severe acne related to steroidogenesis.
8 citations
,
December 2015 in “Daehan han'yi hag'hoeji/Journal of Korean medicine” This study found that transtherapy, a treatment using Korean medicine, significantly improved acne scars, reducing the scarring grade from an average of 3.5 to 1.5 in moderate and severe cases.