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    Glossary Severe Acne

    serious skin condition with large, painful, inflamed cysts and nodules

    Severe acne, also known as cystic acne or nodulocystic acne, is a serious skin condition characterized by large, painful, and inflamed lesions called cysts and nodules. These deep-seated lesions can lead to significant scarring and are often resistant to over-the-counter treatments, typically requiring intervention from a dermatologist, such as prescription medications or specialized therapies.

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    1. Insulin sensitivity, androgens and isotretinoin therapy in women with severe acne Journal of Dermatological Treatment · 2012 · 19 citations
    2. Evaluation of ovarian reserve and function in female patients treated with oral isotretinoin for severe acne: an exploratory study Cutaneous and Ocular Toxicology · 2014 · 13 citations
    3. The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China Clinical Cosmetic and Investigational Dermatology · 2021 · 10 citations
    4. Polymorphisms in Genes Involved in Steroidogenesis in the Development of Severe Acne International Journal of Biomedicine · 2021
    5. Transtherapy for moderate to severe acne scar: a study of 2 cases 2015 · 8 citations
    6. Case 1: Severe acne – not just skin deep Paediatrics & child health · 2008 · 2 citations
    7. Serum irisin: A prognostic marker for severe acne vulgaris Journal of Cosmetic Dermatology · 2018 · 8 citations
    8. BH20 An unintended sequela of hair regrowth: severe Janus kinase inhibitor-associated acneiform eruption in alopecia areata British Journal of Dermatology · 2026
    9. Retrospective Comparison of Inflammatory Markers in Severe Acne Vulgaris Patients and Normal Population Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi · 2026
    10. Measurement and comparison of various androgen levels in women with severe acne, hirsutism, and androgenic alopecia Journal of Steroid Biochemistry · 1986
    11. Combination of Low-Dose Isotretinoin and Pulsed Oral Azithromycin in the Management of Moderate to Severe Acne Clinical Drug Investigation · 2011 · 18 citations
    12. Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris Dermatology Online Journal · 2017 · 10 citations
    13. Depression Risk in the Treatment of Moderate to Severe Acne with Isotretinoin Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg) · 2019 · 2 citations
    14. Efficacy of Fire Needle Therapy Combined with Doxycycline Hydrochloride in the Management of Moderate-to-Severe Acne Vulgaris: A Randomized Controlled Trial Journal of Multidisciplinary Healthcare · 2025
    15. The relationship among androgens, insulin resistanceand ghrelin polymorphisms in post-adolescent malepatients with severe acne vulgaris Advances in Dermatology and Allergology · 2020 · 10 citations
    16. Safety and Clinical Efficacy of KūlarisTM, an Herbal Supplement for Mild to Severe Acne Vulgaris – A 12-Week Randomized, Double Blind, Placebo-Controlled Study Clinical Cosmetic and Investigational Dermatology · 2025
    17. Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne Nature Communications · 2018 · 43 citations
    18. Action of isotretinoin in acne rosacea and gram-negative folliculitis Journal of The American Academy of Dermatology · 1982 · 175 citations
    19. Baldness, acne and testicular germ cell tumours International Journal of Andrology · 2010 · 31 citations
    20. Acne Harper's Textbook of Pediatric Dermatology · 2011 · 2 citations
    21. MORPHOLOGICAL EFFICACY EVALUATION OF GEL WITH CARBON DIOXIDE EXTRACT OF HOPS IN CASE OF COMPLICATED WOUND INFECTION ACNE VULGARIS Wiadomości Lekarskie · 2021 · 1 citations
    22. CORRELATION BETWEEN DEMODEX FOLLICULORUM AND ACNE VULGARIS AMONG ACNE PATIENTS IN BENI-SUEIF GOVERNORATE, EGYPT Journal of the Egyptian Society of Parasitology · 2022
    23. Oral Isotretinoin in HIV-Positive Women with Acne: Report of Three Cases Dermatology · 1998 · 11 citations
    24. Severe Pustular Drug Eruptions From Amivantamab: A Case Series International Journal of Dermatology · 2026 · 1 citations
    25. Novel acne cream seeks FDA approval 2019
    26. Successful treatment of severe atopic dermatitis and alopecia universalis with upadacitinib in a 29-year-old male patient Journal of Allergy and Clinical Immunology Global · 2024 · 5 citations
    27. Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study American Journal of Clinical Dermatology · 2026 · 1 citations
    28. Baricitinib: A Review in Severe Alopecia Areata American Journal of Clinical Dermatology · 2023 · 1 citations
    29. [Treatment of moderately severe virilism of women with Diane and Androcur 10]. PubMed · 1983
    30. Experience with oral tofacitinib in severe alopecia areata with different clinical responses Journal of Cosmetic Dermatology · 2021 · 11 citations