19 citations,
November 2012 in “Journal of Dermatological Treatment” Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.
13 citations,
March 2014 in “Cutaneous and Ocular Toxicology” Oral isotretinoin for severe acne can change hormone levels but does not significantly affect ovarian function.
2 citations,
July 2008 in “Paediatrics & child health” Severe acne in a young girl may indicate underlying hormonal issues.
September 2021 in “International Journal of Biomedicine” Certain gene variations are linked to a higher risk of severe acne, suggesting a genetic influence on the condition.
8 citations,
December 2015 in “Daehan han'yi hag'hoeji/Journal of Korean medicine” Transtherapy significantly improved moderate to severe acne scars without side effects.
10 citations,
January 2017 in “Dermatology Online Journal” Metformin helps treat moderate-to-severe acne when used with other treatments.
8 citations,
September 2018 in “Journal of Cosmetic Dermatology” Lower irisin levels in the blood may indicate more severe acne.
January 1986 in “Journal of Steroid Biochemistry” Women with severe acne, hirsutism, and androgenic alopecia often have higher levels of certain androgens, but the specific pattern can't be predicted just by looking at symptoms.
18 citations,
August 2011 in “Clinical Drug Investigation” Low-dose isotretinoin combined with pulsed azithromycin cleared acne in most patients, with mild side effects.
43 citations,
November 2018 in “Nature Communications” Genetic variations affecting skin structure play a key role in severe acne.
175 citations,
April 1982 in “Journal of The American Academy of Dermatology” Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.
31 citations,
December 2010 in “International Journal of Andrology” Men with testicular cancer were less likely to experience baldness and severe acne.
11 citations,
January 1998 in “Dermatology” Isotretinoin effectively treated severe acne in HIV-positive women, with improved skin and CD4 counts, but some experienced side effects like skin dryness and hair loss.
7 citations,
February 2006 in “Clinical and Experimental Dermatology” Using anabolic steroids 'Sus' and 'Deca' for bodybuilding caused severe acne in a man.
126 citations,
October 1983 in “Journal of The American Academy of Dermatology” Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.
July 2021 in “Journal of emerging technologies and innovative research” Ayurvedic methods successfully treated severe acne in a patient.
25 citations,
November 2022 in “British journal of dermatology/British journal of dermatology, Supplement” Baricitinib for severe alopecia areata is generally safe, with common side effects like infections and acne, and low rates of serious complications.
7 citations,
January 2019 in “Postepy Dermatologii I Alergologii” Certain gene variations might be linked to severe acne in women but not in men.
6 citations,
January 1997 in “Pediatric dermatology” The case suggests a possible link between severe acne and certain bone deformities.
June 2023 in “International Journal of Research in Dermatology” Certain gene variations are linked to severe acne in Egyptian patients and could guide treatment choices.
December 2020 in “Benha Journal of Applied Sciences” People with severe acne tend to have higher levels of betatrophin.
29 citations,
January 2007 in “Dermatologic Clinics” Photodynamic Therapy is an effective treatment for mild to severe acne.
2 citations,
January 2014 in “Springer eBooks” Polycystic Ovary Syndrome (PCOS) often leads to severe acne, and lifestyle changes and hormonal treatments can help manage it.
12 citations,
May 2017 in “Medicine” Oral isotretinoin was recommended for a 21-year-old woman with severe acne.
11 citations,
February 2003 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” Acne and increased body hair in teenage girls are normal but severe cases may need hormone evaluation and treatment can prevent diabetes linked to PCO.
4 citations,
April 2016 in “Journal of Dermatology Research and Therapy” Anti-androgens are safe and effective for treating moderate to severe adult female acne.
1 citations,
March 2022 in “Cureus” A woman with lupus and systemic sclerosis developed severe acne that didn't improve with treatment and died from pneumonia and septic shock.
December 2022 in “Cureus” Adult women with acne in Iraq often have more severe symptoms and hormone-related issues than younger girls with acne.
31 citations,
June 2015 in “British Journal of Dermatology” Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.
September 2024 in “Research Square (Research Square)” Many North African women with acne also have PCOS, showing more severe symptoms and higher testosterone levels.