research Insulin sensitivity, androgens and isotretinoin therapy in women with severe acne
In this study, isotretinoin treatment in women with severe acne increased body weight and triglycerides but did not affect androgens or insulin sensitivity.
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research Evaluation of ovarian reserve and function in female patients treated with oral isotretinoin for severe acne: an exploratory study
This study found that while isotretinoin lowered levels of female hormones in patients with severe acne, it did not significantly impact ovarian reserve function.
research The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China
This study found that specific genetic variants in the CYP21A2 and CYP19A1 genes were associated with severe acne vulgaris among Han Chinese, particularly in male patients.
research Polymorphisms in Genes Involved in Steroidogenesis in the Development of Severe Acne
This study found that SNPs in the MVK, ARPC1B, and CA2 genes may indicate a genetic predisposition for severe acne related to steroidogenesis.
research Transtherapy for moderate to severe acne scar: a study of 2 cases
This study found that transtherapy, a treatment using Korean medicine, significantly improved acne scars, reducing the scarring grade from an average of 3.5 to 1.5 in moderate and severe cases.
research Case 1: Severe acne – not just skin deep
This case report describes a 10-year-old girl with advanced puberty signs and resistant acne, highlighting potential early-onset puberty with associated growth patterns.
research Serum irisin: A prognostic marker for severe acne vulgaris
This study found that serum irisin levels were significantly lower in patients with acne vulgaris compared to healthy controls and were negatively correlated with insulin resistance and disease severity.
research BH20 An unintended sequela of hair regrowth: severe Janus kinase inhibitor-associated acneiform eruption in alopecia areata
In this case study, a woman with alopecia areata experienced significant hair regrowth after starting ritlecitinib but developed an acneiform eruption, leading to the discontinuation of the drug and subsequent hair loss relapse; the eruption suggests a treatment-limiting adverse effect of JAK inhibitors.
research Retrospective Comparison of Inflammatory Markers in Severe Acne Vulgaris Patients and Normal Population
This study found that patients with severe acne vulgaris had different systemic inflammatory indices and hematologic parameters compared to healthy individuals.
research Measurement and comparison of various androgen levels in women with severe acne, hirsutism, and androgenic alopecia
Women with severe acne, hirsutism, and androgenic alopecia often have higher levels of certain androgens, but the specific pattern can't be predicted just by looking at symptoms.
research Combination of Low-Dose Isotretinoin and Pulsed Oral Azithromycin in the Management of Moderate to Severe Acne
This study found that a combination of low-dose isotretinoin and oral azithromycin pulse effectively treats severe acne with an acceptable side effect profile and relatively low relapse rates.
research Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris
This review found that metformin was an effective adjunct therapy for treating moderate-to-severe acne vulgaris in patients without polycystic ovary syndrome or androgen excess.
research Depression Risk in the Treatment of Moderate to Severe Acne with Isotretinoin
This article reviews the use of isotretinoin for acne treatment and its controversial association with depression and suicide, noting limited evidence for a direct link.
research Efficacy of Fire Needle Therapy Combined with Doxycycline Hydrochloride in the Management of Moderate-to-Severe Acne Vulgaris: A Randomized Controlled Trial
This study found that combining fire needle therapy with DHT treatment over eight weeks improved lesion severity, scar symptoms, quality of life, and reduced serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.
research The relationship among androgens, insulin resistanceand ghrelin polymorphisms in post-adolescent malepatients with severe acne vulgaris
This study suggests that the gene rs27647 polymorphism may play a role in the pathogenesis of severe acne vulgaris in post-adolescent male patients.
research Safety and Clinical Efficacy of KūlarisTM, an Herbal Supplement for Mild to Severe Acne Vulgaris – A 12-Week Randomized, Double Blind, Placebo-Controlled Study
In this randomized, placebo-controlled study, Kūlaris supplementation significantly improved quality of life for participants with mild-to-severe acne over 12 weeks, though no significant changes in general skin health measures were observed compared to placebo.
research Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne
This genome-wide association study identified 20 genetic signals at 15 risk loci related to severe acne, revealing new insights into its genetic predisposition, particularly affecting skin structure and maintenance.
research Action of isotretinoin in acne rosacea and gram-negative folliculitis
This study found that oral isotretinoin achieved good to excellent clinical results in treating severe inflammatory acne, severe rosacea, and gram-negative folliculitis.
research Baldness, acne and testicular germ cell tumours
This study found that male pattern baldness and a history of severe acne were inversely associated with testicular germ cell tumors, while taller height showed a positive association.
research Acne
Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.
research MORPHOLOGICAL EFFICACY EVALUATION OF GEL WITH CARBON DIOXIDE EXTRACT OF HOPS IN CASE OF COMPLICATED WOUND INFECTION ACNE VULGARIS
This experimental study on male rats found that a gel containing carbon dioxide extract of hops effectively promoted wound healing in severe acne by enhancing skin regeneration and exhibiting anti-inflammatory, bactericidal, and antimycotic properties.
research CORRELATION BETWEEN DEMODEX FOLLICULORUM AND ACNE VULGARIS AMONG ACNE PATIENTS IN BENI-SUEIF GOVERNORATE, EGYPT
This study found that Demodex folliculorum mites were detected in 1.6% of acne patients, with a higher prevalence in adolescents and those with severe acne.
research Oral Isotretinoin in HIV-Positive Women with Acne: Report of Three Cases
This study observed that isotretinoin was effective in treating acneiform eruptions in HIV-positive women, although side effects like skin xerosis and hair loss were reported.
research Severe Pustular Drug Eruptions From Amivantamab: A Case Series
In this case series, three patients with advanced non-small cell lung cancer experienced severe skin eruptions and scarring alopecia after treatment with amivantamab, highlighting the critical need for prompt recognition and management of these adverse effects to minimize treatment interruptions.
research Novel acne cream seeks FDA approval
A new acne cream effectively reduced acne in trials and awaits FDA approval.
research Successful treatment of severe atopic dermatitis and alopecia universalis with upadacitinib in a 29-year-old male patient
In this case study, a 29-year-old male with severe atopic dermatitis and alopecia universalis experienced an excellent response to treatment with upadacitinib, indicating it may be a promising option for similar patients.
research Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study
In this Italian retrospective study, ritlecitinib 50 mg/day showed effectiveness and good tolerability for treating severe alopecia areata over 24 weeks, achieving significant hair regrowth particularly in adolescents, as well as improvements in eyebrows, eyelashes, nails, and quality of life, with mostly mild adverse effects.
research Baricitinib: A Review in Severe Alopecia Areata
In two phase 3 clinical trials, this study found that adults with severe alopecia areata receiving baricitinib experienced significant hair regrowth on the scalp, eyebrows, and eyelashes over 36 weeks compared to placebo, although longer-term data are needed to fully assess benefits and risks.
research [Treatment of moderately severe virilism of women with Diane and Androcur 10].
In this study, a combined treatment of Androcur and Diane improved acne, seborrhea, hirsutism, and androgenic alopecia in women to varying degrees over two years.
research Experience with oral tofacitinib in severe alopecia areata with different clinical responses
This retrospective pilot study found that oral tofacitinib was more effective in treating alopecia areata than alopecia universalis, but relapses were common after treatment cessation.