The Association of Cytosine-Adenine-Guanine Repeat Polymorphism in the Androgen Receptor Gene with Nodulocystic Acne in Egyptian Patients

    June 2023 in “ International Journal of Research in Dermatology ”
    Nehal Mohamed Zuel-Fakkar, Nader F. Ragab, Abeer A. Shehab, Marion Nagy
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    TLDR Certain gene variations are linked to severe acne in Egyptian patients and could guide treatment choices.
    The study "The association of cytosine-adenine-guanine repeat polymorphism in the androgen receptor gene with nodulocystic acne in Egyptian patients" investigated the role of CAG repeat polymorphism in the androgen receptor gene in nodulocystic acne patients. The study involved 50 participants, 25 males and 25 females. The results showed that females had a higher frequency of longer CAG repeats compared to males, while in the control group, the distribution of CAG number repeats was even in both genders. Both male and female acne patients had significantly lower numbers of CAG repeats compared to controls. The study concluded that the number of CAG repeats affects androgen receptor activity, and therefore, acne development and severity. This suggests that analyzing CAG repeats number in acne patients could be important in treatment strategy, indicating the potential role of antiandrogen therapy in acne patients.
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