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Glossary Drug Reaction with Eosinophilia and Systemic Symptoms

severe allergic reaction to medication causing rash and organ damage

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe, potentially life-threatening hypersensitivity reaction to certain medications. It is characterized by a widespread skin rash, fever, swollen lymph nodes, and involvement of internal organs such as the liver, kidneys, and lungs. Eosinophilia, an elevated level of a type of white blood cell called eosinophils, is a hallmark of this condition. Early recognition and discontinuation of the offending drug are crucial for managing DRESS.

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research Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases

19 citations , June 2011 in “British Journal of Dermatology”

Severe digestive issues in DRESS need early endoscopy for better treatment.

research HHV-6A and HHV-6B in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms

2 citations , January 2014 in “Elsevier eBooks”

This review discusses drug-induced hypersensitivity syndrome and drug reaction with eosinophilia and systemic symptoms, highlighting clinical features, potential viral reactivations, and treatment, but reports no new clinical findings.

Baricitinib for Alopecia Universalis Following Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms

research Baricitinib for Alopecia Universalis Following Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms

June 2026 in “Eurasian Journal of Medicine”

Baricitinib effectively regrew hair in a woman with alopecia universalis after other treatments failed.

research 392 Hair loss after drug reaction with eosinophilia and systemic symptoms: A multicentric retrospective study

April 2023 in “Journal of Investigative Dermatology”

This study reviewed data from three hospitals and found that alopecia after DRESS occurred more often in severe cases, but the rate of corticosteroid treatment did not significantly differ between patients with and without alopecia.

research Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: A retrospective cohort study from Taiwan

157 citations , September 2012 in “Journal of the American Academy of Dermatology”

In this retrospective cohort study, researchers reported that 11.5% of patients with DRESS developed significant long-term autoimmune or renal sequelae, with age influencing the type of sequelae observed.

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