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    Glossary Drug Reaction with Eosinophilia and Systemic Symptoms

    severe allergic reaction to medication causing rash and organ damage

    Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe, potentially life-threatening hypersensitivity reaction to certain medications. It is characterized by a widespread skin rash, fever, swollen lymph nodes, and involvement of internal organs such as the liver, kidneys, and lungs. Eosinophilia, an elevated level of a type of white blood cell called eosinophils, is a hallmark of this condition. Early recognition and discontinuation of the offending drug are crucial for managing DRESS.

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    1. Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases British Journal of Dermatology · 2011 · 19 citations
    2. HHV-6A and HHV-6B in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms Elsevier eBooks · 2014 · 2 citations
    3. Baricitinib for Alopecia Universalis Following Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms Eurasian Journal of Medicine · 2026
    4. 392 Hair loss after drug reaction with eosinophilia and systemic symptoms: A multicentric retrospective study Journal of Investigative Dermatology · 2023
    5. Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: A retrospective cohort study from Taiwan Journal of the American Academy of Dermatology · 2012 · 157 citations
    6. Hair loss after drug reaction with eosinophilia and systemic symptoms (DRESS): A multicentric retrospective case series Journal of Dermatology · 2023 · 2 citations
    7. Viral reactivation in hospitalized patients with drug reaction with eosinophilia and systemic symptoms: A retrospective study from a tertiary medical center in the United States Journal of the American Academy of Dermatology · 2020 · 14 citations
    8. Relapsing Course of Sulfasalazine-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Complicated by Alopecia Universalis and Vitiligo Annals of the Academy of Medicine Singapore · 2018 · 18 citations
    9. Six-year Retrospective Review of Drug Reaction with Eosinophilia and Systemic Symptoms Acta dermato-venereologica · 2012 · 39 citations
    10. Aggressive treatment in paediatric or young patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with future development of type III polyglandular autoimmune syndrome BMJ Case Reports · 2018 · 33 citations
    11. Acute Encephalomyelitis Syndromes Associated with H1N1 Influenza Vaccinations; Erythema Multiforme Secondary to H1N1 Vaccine; Cytolytic Hepatitis Possibly Related to Oral Contraceptives; Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Associated with Lamotrigine: First Report; Behavioral Disinhibition with Baclofen; Minoxidil-Induced Trichostasis Spinulosa of Terminal Hair; Delayed-Onset Mirtazapine-Related Leukopenia Hospital Pharmacy · 2011 · 1 citations
    12. Acneiform Rash Caused by an Unlikely Drug: Topiramate Skin appendage disorders · 2017 · 5 citations
    13. Successful treatment of alopecia universalis with abrocitinib: a case report Journal of Dermatological Treatment · 2023 · 19 citations
    14. Winding the clock back on female androgenetic alopecia British Journal of Dermatology · 2012 · 9 citations
    15. Alopecia areata induzida após síndrome DRESS com rápida resolução Surgical & Cosmetic Dermatology · 2023
    16. P‐51 
Drug‐induced erythema multiforme or drug‐induced pemphigus foliaceus: a case report Veterinary Dermatology · 2004
    17. Chemotherapy and Cutaneous Drug Reactions Springer eBooks · 2015 · 1 citations
    18. Severe and Fatal Phenobarbitone Eruptions The BMJ · 1952 · 14 citations
    19. Dermatologic Side Effects of Systemic Targeted Anticancer Therapy Springer eBooks · 2018
    20. Adverse Cutaneous Reactions to Antidepressants American Journal of Clinical Dermatology · 2002 · 44 citations
    21. Lupus erythematosus: systemic and cutaneous manifestations Clinics in Dermatology · 2006 · 144 citations
    22. Successful rapid subcutaneous desensitization to anakinra in a case of delayed‐type hypersensitivity reaction British Journal of Dermatology · 2016 · 6 citations
    23. Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog Ciência Rural · 2025
    24. Systemic-Onset Juvenile Idiopathic Arthritis with unusual Cutaneous Manifestation and peripheral eosinophilia: Case Report Authorea (Authorea) · 2023
    25. Cutaneous Side Effects of Chemotherapy and Radiotherapy 2016 · 2 citations
    26. Topical imiquimod—Be aware of the unexpected Journal of The American Academy of Dermatology · 2016 · 3 citations
    27. Diagnosis and treatment of cutaneous adverse effects of targeted therapy, antibody–drug conjugates, and immunotherapy in cancer patients: a national consensus statement by the Spanish Society of Medical Oncology and the Spanish Academy of Dermatology and Venereology Clinical & Translational Oncology · 2026
    28. Eosinophilic Pleural Effusion Due to Topical Minoxidil Use 2019 · 2 citations
    29. Acne and Systemic Disease Medical Clinics of North America · 2009 · 76 citations
    30. P-Phenylenediamine-Induced Angioedema-like Facies: A Case Report and Review of Pathomechanisms Indian Dermatology Online Journal · 2026