4 citations
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March 2022 in “Pharmaceutics” This review explores regenerative treatment options for non-scarring alopecia, with a focus on the potential of mesenchymal stem cells for hair regrowth, but it reports no new clinical results.
November 2025 in “IECCMEXICO” This review found that adipose-derived stem cells and stromal vascular fraction have robust clinical benefits in aesthetic surgery, particularly in facial rejuvenation, scar treatment, and volumetric restoration, with favorable safety profiles.
9 citations
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November 2018 in “Drug Discovery Today” This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.
60 citations
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June 2019 in “Ageing Research Reviews” This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.
November 2023 in “Linköping University medical dissertations” This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.
January 2025 in “Research” This perspective highlights research suggesting that cellular senescence in melanocytes may unexpectedly aid hair regeneration by activating hair follicle stem cells, challenging traditional views of senescence as purely detrimental.
March 2026 in “Revista Ibero-Americana de Humanidades, Ciências e Educação” This systematic literature review found that exosome and PRP therapies show promise as effective, minimally invasive options for treating androgenetic alopecia, with clinical benefits potentially superior to or complementary to minoxidil, although standardization and larger clinical trials are needed to confirm long-term safety and efficacy.
320 citations
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December 2018 in “Frontiers in Immunology” This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.
June 2026 in “International Science Journal” This study reviewed recent advances in regenerative technologies for aesthetic and reconstructive medicine and found that adipose-derived stem cells and platelet-rich plasma are well-established for tissue repair due to their safety and effectiveness, while emerging technologies like exosome-based therapies hold future potential.
June 2026 in “THE THERAPIST (Journal of Therapies & Rehabilitation Sciences)” This review highlights the rising interest in exosomes within regenerative medicine, emphasizing their role as communicators that offer standardized manufacturing and ease of use over stem cells. Yet, exosomes complement rather than replace stem cells, each holding unique positions within biological processes.
18 citations
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January 2013 in “International Society of Hair Restoration Surgery” This article discusses the importance of clinical biopreservation for cells and tissues in hair transplantation and regenerative medicine, reporting no new empirical findings.
March 2025 in “International Journal of Pharmaceutical Research and Applications” This study highlights recent biological and technological strategies in anti-aging research aimed at delaying aging and related diseases, improving skin healing, and potentially restoring hair growth.
February 2024 in “Plastic and Reconstructive Surgery – Global Open” This systematic review found that both cellular and acellular stem cell-based therapies are safe and able to improve hair regeneration and density in patients with androgenic alopecia, although some results may be temporary.
June 2026 in “Journal of Biological Studies” This review synthesizes preclinical evidence suggesting that Centella asiatica may extend healthspan by modulating aging hallmarks, enhancing DNA repair, improving mitochondrial function, and reducing inflammation and oxidative stress, potentially paving the way for future gerotherapeutic strategies.
25 citations
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August 2010 in “Acta Biomaterialia” This study achieved a first by successfully forming large quantities of dermal papilla spheroidal microtissues, which retained their hair induction potential, using a micropatterned culture system.
April 2026 in “Aesthetic Cosmetology and Medicine” This literature review examines current anti-aging therapies, focusing on innovative genetic cosmeceuticals enhanced by nanotechnology, which offer targeted and minimally invasive treatment options by effectively delivering anti-ageing genetic elements to skin cells and potentially improving skin health through reduced oxidative stress.
3 citations
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February 2018 in “Vigilância Sanitária em Debate” This review discusses the characteristics and potential clinical applications of platelet-rich plasma in Brazil, emphasizing the need for standardized protocols and regulatory oversight to ensure safety and efficacy.
February 2026 in “Preprints.org” This review synthesizes the latest advances in wound healing and scar management, exploring molecular mechanisms, therapeutic strategies, and providing an evidence-based comparison of topical agents like Dermatix Ultra and Contractubex for scar improvement, aimed at informing clinicians and patients in decision-making.
September 2025 in “Frontiers in Cell and Developmental Biology” In this review, retinoids are highlighted as promising agents for promoting scarless skin regeneration by coordinating cellular and molecular processes that suppress fibrosis, enhance re-epithelialization, promote angiogenesis, and enable hair follicle formation, potentially advancing functional skin repair.
1 citations
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July 2025 in “Frontiers in Endocrinology” This review discusses the dual role of apoptotic vesicles in disease and therapy, emphasizing their potential in cancer treatment and tissue regeneration, but reports no new results.
December 2025 in “Drug Discovery and Molecular Docking (DDMD)” This review highlights how single-cell transcriptomics has advanced understanding of tissue regeneration by revealing cellular diversity and key molecular interactions in animal models, despite methodological challenges, suggesting future applications in developing targeted regenerative therapies.
1 citations
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July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Ashwagandha-derived nanovesicles increased cell proliferation, angiogenesis, and growth factor expression in vitro, suggesting they may have potential as a plant-based alternative or complement to current therapies for hair and skin conditions.
6 citations
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April 2023 in “Cosmetics” In this review, researchers explored the potential of exosomes in cosmetics, skincare, tissue regeneration, and dermatological treatment, noting their promising ability to modulate cellular environments, potentially improving skin health and treating various skin conditions.
July 2024 in “Clinical Cosmetic and Investigational Dermatology” In this review, the authors summarized non-pharmacological therapies that may promote hair growth and regeneration as alternatives to traditional drug treatments and hair transplantation, both of which have notable limitations.
February 2026 in “Exploration” This review summarizes research on scar formation and inhibition mechanisms, discussing emerging therapies like gene therapy and stem cell treatments, but notes ongoing challenges for clinical application, including treatment personalization and outcome sustainability.
May 2026 in “The EMBO Journal” This study explores the complex mechanisms of skin aging, including cellular senescence and disrupted communication, and highlights rejuvenation strategies like gene expression rewiring and microbiome modulation, offering potential frameworks for regenerative therapies and precise interventions in skin and systemic aging.
September 2022 in “Institutional Repositories DataBase (IRDB)” 3D-oxy exosomes may significantly boost hair growth, offering new treatment options for hair loss.
2 citations
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September 2019 in “Romanian Journal of Pediatrics” This review discusses the unique features of fetal wound healing that may enable scarless repair and reports no new experimental findings.
1 citations
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July 2023 in “Cytotherapy” In this study, MSC-derived magnetic nanovesicles combined with a magnetic field increased skin retention and accelerated hair follicle growth in a mouse model of hair regeneration.
21 citations
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January 2023 in “International Journal of Molecular Sciences” This review discusses the role and interactions of the calcium-binding protein S100A6 in cellular processes and its association with various diseases, highlighting the need for further research to fully understand its biological impact.