November 2021 in “International Journal of Trichology” This study found that androgenetic alopecia patients had significantly lower serum levels of paraoxonase 1, which correlated with disease severity and suggests a role of oxidative stress in its pathogenesis.
This systematic review and meta-analysis found that polyphenolic interventions significantly improved hair density and total area hair count in adults with non-scarring alopecia, but substantial heterogeneity was observed.
11 citations
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December 2021 in “Journal of Ginseng Research/Journal of ginseng research” This review discusses the chemical composition, potential health benefits, and extraction methods of red ginseng oil, and reports no new clinical results but emphasizes safety and proposed molecular mechanisms.
8 citations
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January 2020 in “International Journal of Cosmetic Science” This study found that applying a combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol significantly increased hair density in Caucasian women after 1.5 months, potentially due to their synergistic effect on the HIF‐1α pathway.
This study found that PIXE microanalysis effectively detected and quantified trace element changes in hair shafts, revealing a marked decrease in copper after treatment for green hair syndrome.
1 citations
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February 2023 in “Drug Design Development and Therapy” This review discusses the dermatological effects and potential mechanisms of plant adaptogens, emphasizing their role in skin health and aging without presenting new experimental results.
April 2023 in “Journal of Investigative Dermatology” This study found that recombinant type III collagen may aid skin aging management by promoting fibroblast proliferation and migration, with a modest impact on inflammatory marker IL-6, though it did not significantly affect TNF-a secretion in vitro.
7 citations
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July 2018 in “Journal of Functional Biomaterials” This study evaluated a new anti-baldness product, IPSTiC patch hair, designed to treat androgenetic alopecia, and reported that it effectively inhibits NO radical and 5α-reductase activity while maintaining safety and stability, suggesting its potential for topical use.
14 citations
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January 2016 in “Biochemical and Biophysical Research Communications” In this study, researchers found that ginsenoside Re from Panax ginseng increased hair shaft length and duration in mice, comparable to minoxidil, by modulating TGF-β signaling pathways.
13 citations
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January 2017 in “Molecules” This study reported that compounds isolated from Alpinia zerumbet significantly promoted hair cell growth and exhibited anticancer activity in cell cultures, suggesting potential as treatments for alopecia and cancer.
12 citations
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May 2023 in “Molecules” This study identified seven potential enzyme inhibitors from a Polygonum cuspidatum extract using ultrafiltration combined with high-performance liquid chromatography. These compounds showed inhibitory activity against tyrosinase, α-glucosidase, and xanthine oxidase, with most discovered in this extract for the first time.
12 citations
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March 2018 in “Analytical chemistry” This study found that a new analytical approach revealed an increased brain pregnenolone level following finasteride treatment in a mouse model, suggesting potential for improved understanding of neurosteroid roles in brain excitability.
10 citations
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October 2018 in “Journal of molecular and cellular cardiology/Journal of Molecular and Cellular Cardiology” This study identified NM_026333 as a potential anti-aging gene that, when induced, may alleviate proton-induced aging symptoms in CF6-overexpressing and high salt-fed mice.
43 citations
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August 2016 in “Scientific Reports” This animal study found that Cinnamomi cortex water extract reduced prostate weight and improved histological changes in a benign prostatic hyperplasia model, suggesting potential as a treatment.
November 2021 in “Natural product research” This study observed that the aqueous extract of roasted Alocasia macrorrhizos tubers led to hair follicle repigmentation and reduced epidermal thickness in a murine model of Vitiligo.
15 citations
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August 2017 in “International Journal of Molecular Medicine” This study reported that Panax ginseng extract significantly inhibited DKK-1-induced catagen-like changes in human hair follicles by promoting cell proliferation and reducing apoptosis, suggesting it may help mitigate hair loss associated with DKK-1.
August 2024 in “International Journal of Pharmaceutics” This study found that a specially designed water-in-oil microemulsion containing Panax notoginseng saponins improved hair density and other hair health indicators in mice with telogen effluvium and androgenetic alopecia, offering a promising multi-mechanism strategy for alopecia treatment with potentially fewer side effects than traditional methods.
25 citations
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January 2013 in “Journal of Industrial and Engineering Chemistry” This study found that cubosomal suspensions significantly enhanced the hair growth-promoting effects of Thuja orientalis, Polygonum multiflorum Thunberg, and Espinosilla extracts in a mouse model, making them as effective as Minoxidil.
In this randomized controlled trial, PRP combined with redensyl, saw palmetto, and biotin showed superior efficacy in improving androgenetic alopecia grading scores in male patients when compared to PRP with Procapil.
9 citations
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January 2021 in “Acta Cirúrgica Brasileira” This study found that DPG promoted wound healing in rat skin, with increased collagen I density, particularly evident within the first 14 days after injury.
December 2012 in “http://isrctn.org/>” 2 citations
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January 1999 in “Dermatology” 9 citations
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June 2021 in “Journal of Inflammation Research” This study found that Euph E and Euri A showed strong anti-inflammatory activity and modulated cytokine and immune functions in macrophages, related to specific signaling pathways.
September 2022 in “Frontiers in Bioengineering and Biotechnology” This study reports that taxifolin from enzymatic hydrolysis effectively regulates dermal papilla cell apoptosis and promotes hair growth by increasing IGF-1 and reducing TGF-β1, though it shows less inhibition of DHT compared to minoxidil.
3 citations
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December 2019 in “International Journal of Pharmacology” This study found that Poria cocos extract may enhance human follicle dermal papilla cell proliferation through the AKT signaling pathway, indicating its potential for hair growth promotion.
14 citations
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June 2024 in “Food Chemistry X” This review highlights that pomegranate leaf exhibits potential health benefits, such as anti-cancer, anti-diabetic, anti-inflammatory, and neuroprotective effects in vitro and in animal models, but calls for comprehensive human clinical trials to confirm these therapeutic benefits and ensure safety.
This study found that enhancing quercetin bioavailability with EubioQuercetin significantly improved external aging signs in mice and influenced gut microbiota and intestinal gene expression, suggesting potential modulation through the gut microbiota–intestinal barrier axis.
June 2022 in “Pham Ngoc Thach Journal of Medicine and Pharmacy” This study identified key natural compounds such as polyphenols and flavonoids in tongue fern and established optimal extraction conditions using methanol.
7 citations
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July 2018 in “Biological & Pharmaceutical Bulletin” This study found that Phyllanthus urinaria extract displayed significant anti-alopecia properties in a mouse model, showing potential as an anti-5α-reductase agent for androgenic hair loss.
8 citations
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November 2024 in “Phytomedicine” Isoquercitrin helps hair grow by activating certain cell processes.