Effects of Dipotassium Glycyrrhizinate on Wound Healing

    January 2021 in “ Acta Cirúrgica Brasileira ”
    Camila dos Santos Leite, Oscar César Pires, Danielle Gatti Tenis, Jussara Vaz Ziegler, Denise Gonçalves Priolli, Thalita Rocha
    Studysummary This study found that DPG promoted wound healing in rat skin, with increased collagen I density, particularly evident within the first 14 days after injury.
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    The study on dipotassium glycyrrhizinate (DPG) involved 20 Wistar rats and demonstrated that DPG promoted wound healing and skin regeneration, particularly in the first 14 days post-injury. It increased collagen I density in elderly rats and enhanced epidermis and dermis proliferation without inducing fibrosis. The epidermis was thicker after 14 days of treatment but thinner after 21 days. No significant differences in wound size were observed among treated groups, suggesting DPG's potential in enhancing early-stage wound healing. The study highlighted DPG's potential therapeutic role in wound healing, possibly through the activation of the NF-κB pathway, making it beneficial for pharmaceutical and cosmetic applications.
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