Panax Notoginseng Saponins Loaded Water-In-Oil Microemulsion for Alopecia Therapy with Panthenol as Cosurfactant to Reduce Skin Irritation

August 2024 in “ International Journal of Pharmaceutics ”

Shuxuan Li, Yihua Huang, Yingying Sun, Ting Lu, Yating Dong, Shihui Yu, Xuefei Zhang, Haiyan Hu

From the encyclopedia

An essential vasodilator with some anti-androgenic effects

Studysummary This study found that a specially designed water-in-oil microemulsion containing Panax notoginseng saponins improved hair density and other hair health indicators in mice with telogen effluvium and androgenetic alopecia, offering a promising multi-mechanism strategy for alopecia treatment with potentially fewer side effects than traditional methods. Our plain-language summary of this paper — not a Tressless recommendation.

The study developed a water-in-oil microemulsion (PNS ME) using Panax notoginseng saponins (PNS) and D-panthenol to treat alopecia. PNS ME effectively penetrates the skin, targets hair follicles, and promotes hair growth by upregulating β-catenin, VEGF, and Ki67. D-panthenol reduces skin irritation and enhances the microemulsion's efficacy. The treatment significantly improved hair density, pigmentation, and follicle health in mice models, outperforming minoxidil tincture and demonstrating long-term safety and effectiveness.

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