Panax Notoginseng Saponins Loaded Water-In-Oil Microemulsion for Alopecia Therapy with Panthenol as Cosurfactant to Reduce Skin Irritation

    August 2024 in “ International Journal of Pharmaceutics ”
    Shuxuan Li, Yihua Huang, Yingying Sun, Ting Lu, Yating Dong, Shihui Yu, Xuefei Zhang, Haiyan Hu
    TLDR The treatment promotes hair growth, improves hair density, and reduces skin irritation.
    The study developed a water-in-oil microemulsion (PNS ME) using Panax notoginseng saponins (PNS) and D-panthenol to treat alopecia. PNS ME effectively penetrates the skin, targets hair follicles, and promotes hair growth by upregulating β-catenin, VEGF, and Ki67. D-panthenol reduces skin irritation and enhances the microemulsion's efficacy. The treatment significantly improved hair density, pigmentation, and follicle health in mice models, outperforming minoxidil tincture and demonstrating long-term safety and effectiveness.
    Discuss this study in the Community →

    Research cited in this study

    15 / 15 results

    Related Community Posts Join

    6 / 13 results

      community Panax Ginseng is effective against hair loss

       38 upvotes 5 years ago
      Panax Ginseng is suggested as effective against hair loss, with a recommended dose of 400-500mg/day. Users discuss its efficacy and side effects, with some noting no changes and others mentioning insomnia and other side effects.

      community Ginsenoside enriched formulation

      in Treatment 9 months ago
      Panax ginseng, specifically a ginsenoside-enriched formulation, is suggested as a potential hair growth treatment alongside finasteride and minoxidil. The user is considering trying panax ginseng despite limited availability and evidence.

      community Anyone tried Thicair? thoughts?

      in Product 1 month ago
      Thicair is a product combining microneedling and subdural vitamins for hair loss, containing ingredients like Panax Ginseng Root Extract and Copper Tripeptide-1. Users are skeptical, with one calling it "quackery."

      community Unexpected hairline re-growth (taking new supplements)

      in Treatment  32 upvotes 3 years ago
      A user in their mid-30s experienced unexpected hairline regrowth after starting a new supplement stack, despite being on a regimen of finasteride, minoxidil, and Nizoral for over four years. The new supplements include Tongkat Ali, Fadogia Agrestis, Panax Red Ginseng, Vitamin B1, Vitamin D3, Zinc Picolinate, Magnesium Glycinate, Maca, and L-Citrulline.

      community Question regarding Topical finasteride solution

      in Finasteride/Dutasteride  3 upvotes 1 month ago
      A user is using a topical spray containing Finasteride 1% and Minoxidil 5% along with other ingredients like glycerin and aqua, questioning if these are effective carrier agents. They apply it once daily and use a separate 5% Minoxidil solution at night.

      community 30 M diffuse shining/bolding crown - stack

      in Treatment  2 upvotes 1 year ago
      A 30-year-old with diffuse thinning and a balding crown is using a treatment regimen of a 2-in-1 pill containing finasteride, minoxidil, and biotin, along with various supplements. After two weeks, no side effects have been experienced, and updates with pictures will be posted monthly.

    Similar Research

    5 / 352 results