Panax Notoginseng Saponins Loaded Water-In-Oil Microemulsion for Alopecia Therapy with Panthenol as Cosurfactant to Reduce Skin Irritation

    August 2024 in “ International Journal of Pharmaceutics ”
    Shuxuan Li, Yihua Huang, Yingying Sun, Ting Lu, Yating Dong, Shihui Yu, Xuefei Zhang, Haiyan Hu
    TLDR The treatment promotes hair growth, improves hair density, and reduces skin irritation.
    The study developed a water-in-oil microemulsion (PNS ME) using Panax notoginseng saponins (PNS) and D-panthenol to treat alopecia. PNS ME effectively penetrates the skin, targets hair follicles, and promotes hair growth by upregulating β-catenin, VEGF, and Ki67. D-panthenol reduces skin irritation and enhances the microemulsion's efficacy. The treatment significantly improved hair density, pigmentation, and follicle health in mice models, outperforming minoxidil tincture and demonstrating long-term safety and effectiveness.
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