Novel Anti-Aging Gene NM_026333 Contributes to Proton-Induced Aging via NCX1 Pathway

    October 2018 in “ Journal of molecular and cellular cardiology/Journal of Molecular and Cellular Cardiology ”
    Tomohiro Osanai, Makoto Tanaka, Kasumi Mikami, Maiko Kitajima, Toshiko Tomisawa, Koji Magota, Hirofumi Tomita, Ken Okumura
    TLDR The gene NM_026333 slows down aging by affecting the NCX1 pathway and could be targeted for anti-aging treatments.
    The study identified NM_026333 as a novel anti-aging gene that was downregulated in CF6-overexpressing transgenic and high salt-fed mice, which experienced proton-induced aging. The NM_026333 protein, consisting of 269 amino acids, rescued cells from aging hallmarks by binding to NCX1 and suppressing its reverse mode, preventing proton-induced epigenetic changes and autophagy impairments. Additionally, an NCX1 inhibitor extended the lifespan of transgenic mice, suggesting that targeting the NCX1 pathway could be a potential anti-aging therapy.
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