Novel Anti-Aging Gene NM_026333 Contributes to Proton-Induced Aging via NCX1 Pathway

    October 2018 in “ Journal of molecular and cellular cardiology/Journal of Molecular and Cellular Cardiology ”
    Tomohiro Osanai, Makoto Tanaka, Kasumi Mikami, Maiko Kitajima, Toshiko Tomisawa, Koji Magota, Hirofumi Tomita, Ken Okumura
    TLDR The gene NM_026333 slows down aging by affecting the NCX1 pathway and could be targeted for anti-aging treatments.
    The study identified NM_026333 as a novel anti-aging gene that was downregulated in CF6-overexpressing transgenic and high salt-fed mice, which experienced proton-induced aging. The NM_026333 protein, consisting of 269 amino acids, rescued cells from aging hallmarks by binding to NCX1 and suppressing its reverse mode, preventing proton-induced epigenetic changes and autophagy impairments. Additionally, an NCX1 inhibitor extended the lifespan of transgenic mice, suggesting that targeting the NCX1 pathway could be a potential anti-aging therapy.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 21 results

      community Can I get an honest rating of my «Natural Stack?

      in Treatment 1 day ago
      The conversation discusses hair loss treatments, focusing on a "natural stack" including minoxidil, microneedling, a laser helmet, saw palmetto, ketoconazole shampoo, and supplements. Many users suggest adding finasteride or dutasteride for better results, as natural methods alone may not effectively block DHT.

      community How does low level laser therapy?

      in Chat  5 upvotes 7 months ago
      Low-level laser therapy (LLLT) is debated for hair regrowth, with some users suggesting it should be combined with treatments like minoxidil and finasteride for effectiveness. Many users express skepticism about LLLT's efficacy and cost, emphasizing the need for the correct wavelength and quality devices.

      community Frustrated this week, shaving an option after a decade of trying

      in Update  44 upvotes 2 days ago
      The user is frustrated with ongoing hair loss despite using treatments like dutasteride, finasteride, and minoxidil, and is considering shaving their head. They are advised to maintain consistency with medication, consider oral minoxidil, and explore hair transplant options.

    Similar Research

    5 / 1000+ results