Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling

    March 2018 in “ Analytical chemistry ”
    Sheila Sharp, Stephen J. Mitchell, Monique Vallée … Jeffrey Huang
    Studysummary This study found that a new analytical approach revealed an increased brain pregnenolone level following finasteride treatment in a mouse model, suggesting potential for improved understanding of neurosteroid roles in brain excitability.
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    Research cited in this study 5

    1. Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Produced Anxiolytic and Antidepressant-Like Behavioral Effects Neuropharmacology · 2017
    2. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
    3. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    4. A High-Performance Liquid Chromatography–Tandem Mass Spectrometry Assay of the Androgenic Neurosteroid 3α-Androstanediol (5α-Androstane-3α,17β-Diol) in Plasma Steroids · 2005
    5. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002