Overexpression of the 18 kDa Translocator Protein (TSPO) in the Hippocampal Dentate Gyrus Produced Anxiolytic and Antidepressant-Like Behavioral Effects

    June 2017 in “ Neuropharmacology ”
    Lei Li, Wei Wang, Liming Zhang … Yunfeng Li
    Studysummary This study observed that overexpressing TSPO in the hippocampal dentate gyrus of mice led to significant anxiolytic and antidepressant-like effects, potentially mediated by increased allopregnanolone synthesis.
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    Research cited in this study 6

    1. Over-Expression of TSPO in the Hippocampal CA1 Area Alleviates Cognitive Dysfunction Caused by Lipopolysaccharide in Mice Brain Research · 2016
    2. Midazolam Ameliorates the Behavioral Deficits of a Rat Posttraumatic Stress Disorder Model Through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis PLoS ONE · 2014
    3. Role of Neurosteroids in the Anticonvulsant Activity of Midazolam British Journal of Pharmacology · 2011
    4. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010
    5. Involvement of Neurosteroids in the Anxiolytic-Like Effects of AC-5216 in Mice Pharmacology Biochemistry and Behavior · 2008
    6. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006

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