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    Glossary PPAR-gamma agonists

    activate receptors to regulate glucose and lipid metabolism

    PPAR-gamma agonists, also known as Peroxisome Proliferator-Activated Receptor Gamma agonists, are a class of drugs that activate the PPAR-γ receptor, a type of nuclear receptor involved in regulating genes related to glucose and lipid metabolism. These agonists are commonly used in the treatment of conditions like type 2 diabetes because they help improve insulin sensitivity and reduce blood sugar levels.

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    1. PPAR-<i>γ</i> Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017 · 38 citations
    2. PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology Experimental Dermatology · 2019 · 24 citations
    3. Peroxisome Proliferator Activated Receptors Gamma Serum levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case Control Study Research Square (Research Square) · 2022
    4. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010 · 150 citations
    5. The use of oral pioglitazone in the treatment of lichen planopilaris Journal of the American Academy of Dermatology · 2015 · 58 citations
    6. Primary cicatricial alopecia: Recent advances in understanding and management The Journal of Dermatology · 2011 · 44 citations
    7. Lichen planopilaris and frontal fibrosing alopecia: review and update of diagnostic and therapeutic features 2022 · 13 citations
    8. 223 Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor γ Isoforms are Differentially Expressed in Human Skin and Skin Appendages 2022
    9. Folliculocentric papules and alopecia Clinical and Experimental Dermatology · 2014
    10. Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress PLOS genetics · 2014 · 88 citations
    11. Pathogenic Mechanisms and Mechanism‐Directed Therapies for Androgenetic Alopecia: Current Understanding and Future Directions Dermatologic Therapy · 2025
    12. 0866 Role of transcriptional elongation in dermal fat development Journal of Investigative Dermatology · 2025
    13. Peroxisome Proliferator Activated Receptor-Gamma Tissue Expression and Gene Polymorphism in Alopecia Areata in an Egyptian Sample Benha Journal of Applied Sciences · 2023
    14. Faculty Opinions recommendation of Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    15. The role of PPAR<i>γ</i>-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology Experimental Dermatology · 2015 · 84 citations
    16. Nelfb promotes dermal white adipose tissue formation through RNA Polymerase II mediated adipogenic gene regulation Development · 2025
    17. Cicatricial Alopecia Symposium 2011: Lipids, Inflammation and Stem Cells Journal of Investigative Dermatology · 2012 · 4 citations
    18. Mechanism of PPAR&#x3B1; agonist in alopecia areata American Journal of Translational Research · 2025 · 1 citations
    19. Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics? Archives of dermatological research · 2015 · 60 citations
    20. 1380 PPAR-γ modulation as a novel therapeutic strategy for scarring alopecia Journal of Investigative Dermatology · 2018
    21. Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation bioRxiv (Cold Spring Harbor Laboratory) · 2023
    22. Epidermal PPARγ Is a Key Homeostatic Regulator of Cutaneous Inflammation and Barrier Function in Mouse Skin International journal of molecular sciences · 2021 · 9 citations
    23. Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist Archives of dermatology · 2009 · 105 citations
    24. What′s new in cicatricial alopecia? Indian Journal of Dermatology, Venereology and Leprology · 2013 · 16 citations
    25. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018 · 80 citations
    26. How to diagnose a lipodystrophy syndrome Annales d'Endocrinologie · 2012 · 53 citations
    27. Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth Acta dermato-venereologica · 2000 · 51 citations
    28. Lichen Planopilaris Elsevier eBooks · 2018
    29. 1377 Decoding frontal fibrosing alopecia and lichen planopilaris: Macrophages hold the key? Journal of Investigative Dermatology · 2018
    30. 1379 Cell of origin contributes to the melanoma diversity Journal of Investigative Dermatology · 2018