Piperine Reduces Hair Oiliness by Inhibiting Adipogenesis of Hair Stem Cells

    April 2024 in “ Applied biological chemistry ”
    Moon Whan Im, Nackhyoung Kim, Ui-Hyun Park, Hyeon Ho Heo, Soo‐Jong Um
    Image of study
    TLDR Piperine from black pepper can make hair less oily by blocking fat cell development in hair roots.
    The study demonstrates that piperine, a compound found in black pepper, can reduce hair oiliness by inhibiting adipogenesis (fat cell formation) in hair stem cells. The research involved mice on both normal and high-fat diets, with and without piperine supplementation. The high-fat diet increased the size and oiliness of the sebaceous glands (SG), which produce sebum, an oily substance that can make hair appear greasy. However, these effects were significantly reduced by piperine. Piperine also inhibited the expression of adipogenic PPARγ target genes, associated with SG development, and reduced the thickness of subcutaneous fat. These findings suggest that piperine could potentially be used as a treatment for controlling hair oiliness.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 76 results

      community My Research Compilation on Nutrafol

      in Research/Science  9 upvotes 1 year ago
      Nutrafol, a hair loss supplement, has limited and potentially biased research, with one study showing a 10% increase in hair count for women after 6 months but no significant results for men. The user concludes that cheaper, well-studied options like minoxidil may be more effective, especially for men, given the lack of evidence supporting Nutrafol.

      community Dim: high estradiol levels what to do

      in Chat  8 upvotes 4 months ago
      A user is experiencing facial bloating from low-dose topical finasteride due to high estradiol levels and is seeking advice on using DIM to manage this issue, including dosage and brand recommendations.

      community Going to try the theory posted here for the next 3-6 months

      in Treatment  187 upvotes 3 years ago
      User xEternex tries hair regrowth with daily broccoli sprouts, apple extract containing procyanidin b2, and microneedling. Others discuss potential issues with the experiment and share their experiences with vegetable consumption and hair growth.

      community Are there ever going to be any oral DHT blocking treatments in the future?

      in Product  6 upvotes 1 year ago
      The discussion revolves around the need for future oral DHT blockers for hair loss treatment that don't have the side effects of current options like Finasteride and Dutasteride. One user suggests that the future of hair loss treatment will likely be topical anti-androgens, as they can target hair follicles without affecting the entire system.

      community The theory that explains everything. Please help me make this big!

      in Research/Science  2453 upvotes 3 years ago
      The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

      community Best Treatment In The Pipeline?

      in Chat  15 upvotes 4 months ago
      New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

    Similar Research

    5 / 366 results