June 2025 in “Jundishapur Journal of Natural Pharmaceutical Products” This study optimized the extraction process and established quality standards for Pomelo peel essential oil from Vinh Long, Vietnam, identifying specific conditions that improved extraction yield and validating a high-precision method for limonene quantification.
May 2025 in “Veterinary Medicine and Science” In this study, oral melatonin given to male Pomeranian dogs with Alopecia X improved semen quality and testicular blood flow in a dose-dependent manner, but altered hormonal balance, indicating complex effects that require further investigation for long-term implications.
January 2024 in “Veterinary Science and Medicine Journal” In this case report, a 1.5-year-old Pomeranian named Beb with respiratory and skin issues was diagnosed with pneumonia and demodecosis; following a two-week treatment including antibiotics, ivermectin, and supportive care, Beb's symptoms resolved, and hair regrowth was observed.
30 citations
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October 2009 in “Journal of Veterinary Internal Medicine” This report describes a unique case of hereditary vitamin D-resistant rickets (HVDRR) in a dog, caused by a VDR gene mutation resulting in severe hypocalcemia and bone issues, which presented with symptoms similar to those observed in humans.
12 citations
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July 2015 in “Veterinary Dermatology” This study observed that microneedling induced significant hair regrowth and reduced hyperpigmentation in two Pomeranians with alopecia X, with stable results over 12 months.
October 2025 in “Journal of Veterinary Clinics” In this case study, a Pomeranian was diagnosed with vaccine-induced ischemic dermatopathy, where different medication regimens gradually improved hair regrowth, though some lesions persisted after tapering treatment.
202 citations
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July 2022 in “Biomedicine & Pharmacotherapy” This review compiles and discusses the ethnomedicinal uses, pharmacological activities, and phytochemistry of pomegranate, suggesting potential future applications in drug discovery for various ailments but reports no new clinical results.
21 citations
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February 2023 in “Pharmaceuticals” This study reports that extracts from pomegranate leaves contain bioactive compounds with antioxidant, antimicrobial, and skin-beneficial properties, suggesting their potential use in nutraceutical and cosmeceutical applications.
17 citations
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September 2024 in “Cosmetics” This study assessed the antioxidant properties and contents of carotenoids and chlorophylls in 10 plant oils, finding fenugreek seed oil to be highest in carotenoids and pomegranate oil most active against free radicals, highlighting their potential as natural materials with antioxidant benefits.
5 citations
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January 2024 in “Advances in Pharmacological and Pharmaceutical Sciences” This review explored the biological properties of Punica granatum, noting its antioxidant, anti-inflammatory, and antimicrobial activities, and highlighted its potential as a therapeutic agent for various conditions; however, more extensive clinical trials are needed to confirm its effectiveness and safety.
2 citations
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August 2013 in “The Lancet. Diabetes & endocrinology” This report discusses the FDA's third denial of approval for Aveed, a long-acting testosterone injection by Endo Pharmaceuticals, citing continued safety concerns including severe side effects.
2 citations
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April 2020 in “International journal of research in pharmaceutical sciences” This review discusses the use of ten common Malaysian medicinal plants in cosmetic formulations for treating skin and hair conditions and reports no new clinical results.
1 citations
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December 2022 in “Research journal of topical and cosmetic sciences” This study evaluated a polyherbal shampoo containing natural ingredients and found it demonstrated good froth stability, cleansing ability, and conditioning activity, but called for further validation of its overall quality.
1 citations
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January 2013 in “Springer eBooks” Cosmeceuticals may benefit skin health but need more research for efficacy and safety confirmation.
April 2026 in “Inflammopharmacology” This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.
In this study, applying a 5% concentration of pomegranate peel extract significantly enhanced hair growth on male rabbits, showing results comparable to the positive control using 2% Minoxidil, but higher concentrations or lower concentrations did not perform as well.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This research describes how herbal hair serums, containing natural components like pomegranate peel and aloe vera, can support hair health by nourishing the scalp, stimulating follicles, and enhancing hair strength and shine, aligning with growing interest in herbal and chemical-free personal care products.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This study reviews the benefits of herbal hair serums, highlighting their antioxidant and anti-inflammatory properties from natural ingredients like pomegranate peel and aloe vera, which nourish the scalp and promote healthy hair growth while improving hair strength and texture.
April 2025 in “International Journal of Medical Science and Diagnosis Research” This study developed a polyherbal shampoo using herbal extracts as an alternative to chemical-based shampoos, aiming to provide a safer and more effective hair care option.
September 2024 in “Sasambo Journal of Pharmacy” This study formulated and tested a pomegranate leaf shampoo with antifungal properties, identifying an optimal composition of 5.5% SLS and 15.5% cocamide DEA, showing good foam stability, appropriate pH, and viscosity in lab tests.
May 2024 in “EAS Journal of Pharmacy and Pharmacology” In this study, researchers used molecular docking to show that compounds from pomegranate peels, such as apigenin, luteolin, and taxifolin, effectively inhibit the enzyme 5α-reductase, suggesting potential anti-alopecic properties.
June 2022 in “Research journal of topical and cosmetic sciences” This study found that taking 500mg of Trichovitals® daily for 12 weeks was linked to significant improvements in hair thickness, reduced hair loss, and enhanced hair growth in young adults.
March 2021 in “International journal for research in applied science and engineering technology” In this study, researchers explored the use of natural herbal hair dyes made from tannin-producing plants like henna and pomegranate, reporting that these dyes can permanently color hair without causing damage or irritation, unlike synthetic dyes.
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” This review explores the role of advanced glycation end products in skin aging and their interaction with oxidative stress, but reports no new clinical findings.
18 citations
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October 2017 in “PLOS ONE” This study found that in Pomeranians with Alopecia X, key genes in the Wnt and Shh signaling pathways and stem cell markers are downregulated, which may explain the absence of anagen hair follicles.
1 citations
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October 2023 in “Veterinary Dermatology” This study found that in Pomeranian dogs with alopecia X, dermoscopic evaluations can supplement diagnoses, and transverse skin biopsy sections better assess hair follicle density and identify growth arrest phases compared to longitudinal sections.
This monograph reviews the historical and contemporary use of pomegranate in medicine, detailing its chemical components and applications across various medical fields including oncology, dentistry, and urology.
July 2010 in “Hair transplant forum international” This piece honors the late Cheryl Pomerantz, RN, for her contributions to the International Society of Hair Restoration Surgery, noting her significance to the organization but reports no new research findings.
10 citations
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September 2013 in “Veterinary dermatology” This study found that medroxyprogesterone injections led to partial or complete hair regrowth in some Pomeranian dogs with alopecia X, though their IGF-1 levels remained unchanged.
January 2016 in “Journal of animal research” This study found significant correlations for copper and zinc levels between hair and plasma in Pomeranian and Labrador dogs, but no significant correlation for iron.