Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets in a Pomeranian Dog Caused by a Novel Mutation in the Vitamin D Receptor Gene

    October 2009 in “ Journal of Veterinary Internal Medicine ”
    D. N. Levine, Zhou Y, R.J. Ghiloni … D. Feldman
    Studysummary This report describes a unique case of hereditary vitamin D-resistant rickets (HVDRR) in a dog, caused by a VDR gene mutation resulting in severe hypocalcemia and bone issues, which presented with symptoms similar to those observed in humans.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 6

    1. Interactions of the Vitamin D Receptor with the Corepressor Hairless Journal of Biological Chemistry · 2007
    2. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005
    3. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004
    4. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    5. Hereditary 1,25-Dihydroxyvitamin D-Resistant Rickets KARGER eBooks · 2003
    6. Analysis of the Relation Between Alopecia and Resistance to 1,25-Dihydroxyvitamin D Clinical Endocrinology · 1986