Optimization of Pomegranate Leaf Extract Shampoo Formula Using Simplex Lattice Design Method

    September 2024 in “ Sasambo Journal of Pharmacy ”
    Syifaul Jannah, Wahida Hajrin, Nisa Isneni Hanifa
    🚨 The study is relevant to scalp health and human hair due to its focus on anti-dandruff shampoo, which can impact scalp conditions, but it does not directly address hair loss or alopecia.
    TLDR The optimal pomegranate leaf extract shampoo formula effectively combats dandruff without causing hair loss.
    This study optimized an anti-dandruff shampoo formula using ethanol extract from pomegranate leaves, known for their antifungal properties. Using the Simplex Lattice Design method, 8 formulas were tested, and the optimal formula contained 5.5% SLS and 15.5% cocamide DEA. The resulting shampoo had a black color, menthol odor, gel form, and homogeneous mixture, with foam stability of 81.83%, foam height of 9.30 ± 0.26 cm, pH of 5.91 ± 0.45, and viscosity of 1646.66 ± 220.23 cP. The extract's antifungal efficacy is supported by the presence of alkaloids, flavonoids, tannins, and saponins.
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