The study investigates the potential of phytocompounds from Punica granatum (pomegranate) peel as an anti-alopecia treatment by targeting the enzyme 5-α-reductase, which is involved in hair loss. Using molecular docking studies, the research identified that lead compounds from the pomegranate peel, specifically Apigenin, Luteolin, and Taxifolin, effectively bind to the 5-α-reductase enzyme with binding energies of -7.15, -7.66, and -7.07 kcal/mol, respectively. These findings suggest that these compounds exhibit strong inhibitory activity against the enzyme, indicating their potential as effective anti-alopecia agents.
14 citations,
April 2021 in “Biology” Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.
79 citations,
January 2017 in “Dermatology practical & conceptual” Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.
16 citations,
September 2018 in “Journal of Ethnopharmacology” Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.
1 citations,
November 2023 in “Naunyn-Schmiedeberg's archives of pharmacology” Henna has potential health benefits and can treat various conditions, but more research is needed to confirm safety and effectiveness.
57 citations,
October 2021 in “Journal of ethnopharmacology” Indian herbal medicine shows promise for treating skin diseases but needs more research to prove effectiveness.
14 citations,
April 2021 in “Heliyon” Pomegranate leaf extract may help with hair growth, dandruff, and lice.
1 citations,
January 2020 The pomegranate-based herbal shampoo works well and is safe for daily use.
