7 citations
,
December 2016 in “Journal of The Taiwan Institute of Chemical Engineers” This study found that porcine platelet-rich plasma can be a commercially viable replacement for fetal bovine serum with similar effectiveness in promoting human hair follicle cell growth.
4 citations
,
July 2023 in “Journal of Cosmetic Dermatology” This study found that adapalene-loaded microemulsions significantly enhanced the drug's penetration through guinea pig skin compared to an aqueous suspension, with factors like surfactant ratios and the water-oil phase balance affecting the transfollicular drug delivery efficiency.
1 citations
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September 2025 in “Wound Repair and Regeneration” This study found that an acellular dermal matrix derived from tilapia skin significantly accelerated wound healing and improved tissue regeneration quality in mouse and pig models compared to a commercial porcine-derived matrix, suggesting its potential as a safe, cost-effective bioscaffold for skin repair.
1 citations
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January 2024 in “Advances in Engineering Technology Research” This study found that bone marrow mesenchymal stem cells from Guizhou miniature pigs showed stable growth and multidirectional differentiation potential, making them ideal for tissue engineering applications.
August 2025 in “Annals of Medicine” This study found that mycophenolate mofetil can enhance skin pigmentation in vitiligo models by activating the WNT signaling pathway and increasing melanin-related gene expression.
May 2025 in “Lithuanian University of Health Sciences” This study found that different diets had a negligible impact on guinea pigs' hair structure and did not significantly alter their health parameters, suggesting both tested diets met their nutritional needs without affecting their well-being.
March 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers found no monthly variations in perceived health of Hartley Albino guinea pigs or correlations with experimental completion rates, suggesting mild hair or weight loss may not impact their use in cardiac research.
February 2017 in “Spectrum Research Repository (Concordia University)” This study confirmed porcine PRP's commercial viability as a fetal bovine serum replacement, showing higher growth factor levels and stability, without increasing human follicle dermal papilla cell proliferation compared to FBS.
January 1993 in “Di-Si Junyi Daxue xuebao” This study found that type III collagen was significantly more abundant in the recovering traumatic skin of guinea pigs compared to normal skin, indicating it may play a role in tissue repair.
16 citations
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April 2018 in “Animal Genetics” This study identified two significant genomic regions potentially involved in hair development and growth in Casertana pigs, highlighting FOXN3 and ARHGEF10 as candidate genes associated with a hairless phenotype.
26 citations
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July 2007 in “Biochemical Pharmacology” This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.
353 citations
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November 2014 in “Molecular immunology” This review discusses the immune functions of porcine skin and proposes a classification of dendritic cell subsets based on similarities to human skin, but it reports no new clinical results.
53 citations
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June 2020 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review discusses the development and use of various animal models for studying psoriasis, highlighting their strengths and limitations, but reports no new experimental results.
11 citations
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December 2024 in “Wound Repair and Regeneration” In this study, researchers created the WRAHPS Guidelines to standardize the reporting of preclinical wound healing studies, aiming to improve transparency, enable comparative analysis, and support the development of human clinical trials for wound healing disorders.
June 2023 in “Journal of Pharmaceutical and Health Research” In this study with guinea pigs, a hair tonic containing 0.001% caffeine significantly stimulated hair growth, showing higher effectiveness with an average hair length of 18.294 mm compared to a tonic with 0.005% caffeine concentration, which resulted in an average hair length of 16.610 mm.
1 citations
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September 2024 in “Frontiers in Cell and Developmental Biology” Pigs are a good model for studying human hair growth and disorders.
3 citations
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September 1975 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” This study found that pigs fed a fat-free diet had significantly less body dry matter and ether extract compared to those consuming a diet with corn oil, although weight gain was unaffected by the fat content.
2 citations
,
January 2011 in “Feed Review” This study found that weanling pigs fed a diet supplemented with 0.029% iron glycine chelate showed improved growth performance and better hair color compared to those receiving ferrous sulfide.
1 citations
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November 2016 in “Experimental and Therapeutic Medicine” In this study using guinea pigs, the low-dose 800 nm semiconductor laser was found to effectively treat skin blackheads and coarse pores by promoting hair follicle cell apoptosis, while maintaining PCNA expression levels in sebaceous glands.
1 citations
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January 2010 This study in humans and pigs found that finasteride metabolism is significantly influenced by CYP3A4, with induced metabolism decreasing and inhibited metabolism increasing plasma exposure of the drug.
This chapter reviews fungal skin diseases in pigs, including urticarial and autoimmune conditions, but does not report new clinical findings.
14 citations
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January 2004 in “Journal of Biochemical and Molecular Toxicology” This study found that sudden hair loss in guinea pigs may serve as a potential biomarker for subacute exposure to mustard gas, and pre-treatment with N-acetylcysteine could prevent this hair loss.
13 citations
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March 1998 in “Journal of Biomedical Materials Research” This study found that island grafting in guinea pigs enabled the isolated study of early skin regeneration processes, distinguishing them from natural wound closure mechanisms like epithelialization and contraction.
9 citations
,
September 1977 in “Journal of Small Animal Practice” In this study, gamma benzene hexachloride washes successfully resolved skin disease in guinea pigs affected by Trixacarus caviae, after confirmation via skin scrapings.
8 citations
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September 1981 in “Zentralblatt für Veterinärmedizin Reihe A” In this animal study, pigs on a biotin-deficient diet showed significant hair loss, weak and brittle claws, and skin lesions after 8–10 weeks, with tissue necrosis observed microscopically after 15 weeks.
5 citations
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January 2021 in “Wiadomości Lekarskie” This study developed a protocol for acellular dermal matrix manufacturing from pig skin, demonstrating effective removal of cellular components while preserving the collagen scaffold's structural organization through a series of physical and chemical treatments.
3 citations
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April 2023 in “Veterinary sciences” This study found that among Large White × Min pigs, 15 significant copy number variation regions were associated with villi hair traits, and identified candidate genes potentially linked to cold resistance, suggesting implications for breeding cold-resistant pigs.
3 citations
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January 2019 in “Jikken doubutsu ihou/Jikken doubutsu/Experimental animals/Jikken Dobutsu” This study reported that knocking out the HR gene in pigs using CRISPR/Cas9 led to hairless eyelids and abnormalities in the thymus and peripheral blood, suggesting pigs as a model for human HR-related hair disorders.
3 citations
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July 1969 in “PubMed” This study found that unilateral neutron irradiation in pigs significantly decreased the uptake of radioactive zinc in blood, impaired growth, and led to decreased organ weights and hair pigmentation changes on the irradiated side.
2 citations
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December 2013 in “Xenobiotica” This study found that the metabolic profile of finasteride in pigs closely matches that of humans, supporting the use of pigs for studying human drug metabolism.