Evidence of Hair Loss After Subacute Exposure to 2-Chloroethyl Ethyl Sulfide, a Mustard Analog, and Beneficial Effects of N-Acetylcysteine

January 2004 in “ Journal of Biochemical and Molecular Toxicology ”

Diptendu Chatterjee, Sanjoy Mukherjee, Milton Smith, Salil K. Das

2-chloroethyl ethyl sulfide mustard gas analog hair loss hair follicle regression keratinocyte proliferation N-acetylcysteine CEES NAC

TLDR Mustard gas exposure causes hair loss, but treating with N-acetylcysteine can prevent it.

In 2004, researchers discovered that guinea pigs exposed to 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog, experienced significant hair loss without visible skin damage, indicating that hair loss could be a biomarker for subacute mustard gas exposure. Microscopic examination showed hair follicle regression and decreased keratinocyte proliferation. Pre-treatment with N-acetylcysteine (NAC) was found to prevent this hair loss, suggesting NAC's potential as a treatment for mustard gas toxicity. The exact number of guinea pigs involved in the study was not mentioned.

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