Evidence of Hair Loss After Subacute Exposure to 2-Chloroethyl Ethyl Sulfide, a Mustard Analog, and Beneficial Effects of N-Acetylcysteine

    January 2004 in “ Journal of Biochemical and Molecular Toxicology ”
    Diptendu Chatterjee, Sanjoy Mukherjee, Milton Smith, Salil K. Das
    Image of study
    TLDR Mustard gas exposure causes hair loss, but treating with N-acetylcysteine can prevent it.
    In 2004, researchers discovered that guinea pigs exposed to 2-chloroethyl ethyl sulfide (CEES), a mustard gas analog, experienced significant hair loss without visible skin damage, indicating that hair loss could be a biomarker for subacute mustard gas exposure. Microscopic examination showed hair follicle regression and decreased keratinocyte proliferation. Pre-treatment with N-acetylcysteine (NAC) was found to prevent this hair loss, suggesting NAC's potential as a treatment for mustard gas toxicity. The exact number of guinea pigs involved in the study was not mentioned.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community 2 years on treatment (stack update)

      in Progress Pictures  456 upvotes 1 week ago
      A user shared their hair regrowth progress using Dutasteride, topical Minoxidil, Spironolactone, and Estradiol Valerate injections as part of hormone replacement therapy for transitioning. They experienced significant hair improvement and personal satisfaction but caution against this approach for non-transitioning individuals due to irreversible changes.

      community 2.5 mg/ED dut and 1% pyrilutamide, still getting itch?

      in Update  1 upvotes 1 week ago
      The user switched from finasteride to 2.5 mg dutasteride daily and added 1% pyrilutamide to address persistent scalp itch, but the itch remains. They also use 2% ketoconazole and 2.5% selenium sulfide shampoo for temporary relief.

      community 2 months and a half on min + fin

      in Progress Pictures  836 upvotes 1 week ago
      The user has been using topical minoxidil, oral finasteride, and nizoral shampoo for almost three months, along with supplements like biotin and vitamin D3, and reports noticeable hair regrowth without side effects. They aim to have more hair for a wedding in June and are considering using hair fibers for temporary enhancement.

      community 2.5mg Oral Minox per day, Derma roll 1x/week, Ketoconazole Shampoo 3x/week. 2 month progress. Currently have Oral Dut and Min on the way in the mail. We just might make it.

      in Progress Pictures  19 upvotes 1 week ago
      The conversation is about hair loss treatment progress using 2.5mg oral Minoxidil daily, derma rolling weekly, and Ketoconazole shampoo thrice weekly, with plans to add oral Dutasteride. Users discuss the potential benefits and timing of using Dutasteride for hair recovery.

      community 2 months on oral Finasteride + topical minoxidil

      in Progress Pictures  763 upvotes 2 weeks ago
      Significant hair regrowth was achieved in two months using oral finasteride, topical minoxidil, microneedling, and Nizoral shampoo. Some users mentioned side effects of finasteride, like low libido and pain, and recommended consulting a doctor or trying topical alternatives.

    Similar Research

    5 / 1000+ results