Low-Frequency Dual-Frequency Ultrasound-Mediated Microbubble Cavitation for Transdermal Minoxidil Delivery and Hair Growth Enhancement

March 2020 in “ Scientific Reports ”

Ai-Ho Liao, Keng-Hsien Lin, Ho-Chiao Chuang, Chih-Hung Tsai, Yi-Chun Lin, Chih-Hung Wang, Cheng-Ping Shih, Hao-Li Liu

dual-frequency ultrasound microbubble cavitation minoxidil transdermal delivery hair growth enhancement Evans blue Rogaine

TLDR Using dual-frequency ultrasound with microbubbles can potentially improve the delivery of hair growth treatment through the skin and enhance hair growth.

In 2020, a study was conducted using pigskin samples and C57BL/6 mice to test the effectiveness of dual-frequency ultrasound-mediated microbubble cavitation for enhancing the delivery of minoxidil, a common hair growth treatment. The results showed that this method significantly increased the penetration depth of the model drug, Evans blue, especially in the group with 10-fold diluted microbubbles. The in vivo experiments showed a significantly higher concentration of minoxidil in the group treated with dual-frequency ultrasound and 10-fold diluted microbubbles compared to other groups. The study concluded that dual-frequency ultrasound-mediated microbubble cavitation could potentially enhance transdermal minoxidil delivery and hair growth.

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Research cited in this study

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research Effectiveness of a Layer-by-Layer Microbubbles-Based Delivery System for Applying Minoxidil to Enhance Hair Growth

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Low-Frequency Dual-Frequency Ultrasound-Mediated Microbubble Cavitation for Transdermal Minoxidil Delivery and Hair Growth Enhancement

research Low-Frequency Dual-Frequency Ultrasound-Mediated Microbubble Cavitation for Transdermal Minoxidil Delivery and Hair Growth Enhancement

14 citations, March 2020 in “Scientific Reports”

Using dual-frequency ultrasound with microbubbles can potentially improve the delivery of hair growth treatment through the skin and enhance hair growth.