A Porcine Model for the Development and Testing of Preoperative Skin Preparations
April 2022
in “
Microorganisms
”
Studysummary In this study, clinically used preoperative skin preparations with povidone iodine and chlorhexidine gluconate did not meet FDA log-reduction standards for bacterial bioburden in a porcine model, suggesting persistent infection risks.
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The study developed a porcine model to test the effectiveness of preoperative skin preparations (PSPs) using 10 Yorkshire pigs, comparing povidone iodine (PVP-I) and chlorhexidine gluconate (CHG). Both PSPs reduced skin bioburden but failed to meet the FDA's 2–3 log10-reduction criteria, achieving only 1.46 log10 and 0.58 log10 reductions, respectively. PVP-I showed greater bioburden reduction than CHG, with significant differences confirmed by statistical analysis. The study identified 186 bacterial isolates, noting the persistence of certain bacteria despite treatment. The porcine model, resembling human skin, proved useful for testing and developing more effective PSPs, highlighting the need for improved technologies to address deeper skin flora and reduce surgical site infection risks.
