Efficacy of CD101, a Novel Echinocandin, in the Treatment of Dermatophytosis Using a Guinea Pig Model

The study evaluated the efficacy of CD101, a novel echinocandin, in treating Trichophyton mentagrophytes dermatophytosis in guinea pigs. Male albino guinea pigs were treated with subcutaneous CD101 at doses of 10, 20, and 40 mg/kg, compared to a positive control (terbinafine 10 mg/kg) and a vehicle control. Results showed that CD101 had significant clinical and mycological efficacy, with percent efficacies of up to 98.4% clinically and 98.5% mycologically, outperforming terbinafine. The findings indicated that CD101, administered once weekly, was highly effective in treating dermatophytosis in this model.