148 citations
,
April 2009 in “Molecular Pharmaceutics” This study reports that three synthesized PSMA-targeted radioimaging agents demonstrated high affinity and specific localization to prostate cancer tumors in a mouse model, highlighting their potential for cancer detection and monitoring.
125 citations
,
September 2019 in “Journal of Clinical Immunology” This review summarizes recent advances in Treg cell biology, focusing on Foxp3's role in immune regulation and therapeutic reprogramming for immune dysregulatory disorders, but reports no new clinical results.
112 citations
,
November 2023 in “Nano-Micro Letters” This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
103 citations
,
November 2014 in “Journal of Cell Biology” This study found that overexpression of miR-214 in keratinocytes inhibits hair follicle development and cycling by targeting β-catenin in the Wnt signaling pathway.
85 citations
,
July 2025 in “Nature Communications” This review examines the evolving field of nanozymes, highlighting their unique properties and biocatalytic capabilities that challenge traditional concepts of biocatalysis, with implications for sustainable applications and potential roles in physiological processes and disease pathogenesis.
77 citations
,
August 2025 in “Signal Transduction and Targeted Therapy” This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.
68 citations
,
March 2019 in “Advanced Healthcare Materials” This review assesses the benefits and limitations of various supramolecular hydrogels, including polymeric and peptide-based types, for wound healing, but reports no new clinical results.
60 citations
,
July 2011 in “Stem Cells and Development” This review discusses recent findings on hair follicle morphogenesis and regeneration, focusing on molecular signals and stem cells, and suggests that understanding these processes may aid in developing new strategies for wound healing.
57 citations
,
September 2017 in “Journal of controlled release” This review discusses recent advances in using nanocarrier-loaded gels for various medical applications and reports no new clinical results, highlighting potential advantages in therapeutic strategies.
52 citations
,
November 2013 in “European Journal of Pharmaceutical Sciences” This study examined different polymersome systems for topical finasteride delivery and found that chitosan-decorated C7 polymersomes may enhance skin retention and provide controlled drug release compared to non-decorated systems in laboratory settings.
51 citations
,
June 2021 in “Signal Transduction and Targeted Therapy” This review article summarizes recent strategies to enhance the precise control of CRISPR/Cas9 gene editing, addressing tissue-specific challenges and off-target effects by exploring various activation methods like cell-specific promoters and small molecules.
47 citations
,
November 2012 in “Pharmaceutical research” This study found that surface modified nanoparticles showed increased skin permeation and improvement in allergic contact dermatitis, independent of the follicular pathway.
46 citations
,
March 2019 in “Journal of Pineal Research” The study found that melatonin treatment in early postnatal cashmere goats increased both the quantity and quality of cashmere by promoting secondary hair follicle development and enhancing antioxidant enzyme activities.
45 citations
,
January 2020 in “International Journal of Molecular Sciences” This review discusses the potential of plant polyphenols to overcome multidrug resistance in various solid cancers and reports no new experimental results; further research is suggested.
43 citations
,
January 2012 in “Biological Research” This review discusses the embryonic origins and characteristics of various stem cell populations in the skin, but it provides no new experimental results.
38 citations
,
June 2015 in “Expert Opinion on Therapeutic Targets” This review explores potential indications for prolactin receptor inhibitors beyond breast and prostate cancers, emphasizing the need for potent antibodies to further research prolactin receptor expression.
32 citations
,
January 1990 in “Clinical Endocrinology” This study found that women with female pattern androgenic alopecia have significantly higher levels of certain androgens and androgen sulfates compared to normal premenopausal women, suggesting markers for diagnosis and treatment efficacy.
28 citations
,
January 2017 in “Critical Reviews in Therapeutic Drug Carrier Systems” This review classifies engineered nanomaterials by composition and application in biomedicine, highlighting diverse uses like regenerative medicine and potential occupational side effects, but reports no new clinical results.
25 citations
,
September 2018 in “Molecular Biology of the Cell” This study found that in mice lacking EGFR, elevated Wnt signaling disrupts hair follicle development by affecting cell proliferation and differentiation, revealing a critical role for EGFR in regulating these processes.
25 citations
,
December 2013 in “Journal of Investigative Dermatology Symposium Proceedings” This review discusses recent advancements in cutaneous drug delivery technologies and the potential of transfollicular pathways for improved treatment of skin conditions, but reports no clinical results.
24 citations
,
July 2017 in “Structure” In this study, researchers found that ligand homodimerization controls the receptor binding specificity of the FGF9 subfamily, preventing off-target activation of FGFR "b" isoforms.
23 citations
,
December 2020 in “Frontiers in Cell and Developmental Biology” This review explores recent insights into how intrinsic gene oscillations and molecular interactions in hair follicle stem cells contribute to their regenerative potential, with potential implications for regenerative medicine, but reports no new clinical results.
21 citations
,
November 2022 in “Frontiers in immunology” This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.
19 citations
,
September 2020 in “Pharmaceutics” This study investigated a new formula called SV-loaded nanospanlastics for topical application to treat androgenic alopecia. It showed similar effectiveness to minoxidil lotion but with fewer adverse effects when used to enhance dermal delivery and efficacy of sodium valproate.
17 citations
,
December 2019 in “Stem Cells International” This review examines the recent progress in using bioactive molecules for skin regenerative medicine and reports no new clinical results; the authors suggest this method could become a promising strategy for in situ skin regeneration.
17 citations
,
June 2017 in “British Journal of Dermatology” This review examines the interaction between hedgehog and Wnt/β-catenin signalling in hair follicles and basal cell carcinoma, linking Hh pathway inhibition to both tumor regression and alopecia.
16 citations
,
July 2020 in “Advanced functional materials” This review discusses the development and application of cell-derived matrices in regenerative medicine and disease modeling, presenting various fabrication techniques and future perspectives, but reports no new results.
15 citations
,
November 2017 in “Drug Development and Industrial Pharmacy” This study found that the optimized finasteride-loaded lyophilized tablets using a self-nanoemulsifying drug delivery system improved bioavailability in human volunteers compared to the marketed finasteride product.
13 citations
,
July 2024 in “Heart Failure Reviews” This review compiles data on how the apelinergic system may protect against heart damage caused by doxorubicin cancer treatment, suggesting its potential to mitigate cardiotoxicity, though further research in chronic models is needed to confirm these effects and mechanisms.
10 citations
,
December 2014 in “Journal of Pharmaceutical and Biomedical Analysis” Finasteride's polymorphic form affects capsule quality and drug effect, requiring strict control.