Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

The document reviews the development and application of nanozymes, which are synthetic enzyme-like materials, in cancer theranostics. Since their discovery in 2007, nanozymes have gained attention due to their high catalytic activity, cost-effectiveness, and stability. The review discusses over 270 research articles from the past five years, covering the classification, catalytic mechanisms, and design of nanozymes using advanced methods like density functional theory and machine learning. It highlights the potential of nanozymes in tumor therapy, emphasizing their ability to operate in the tumor microenvironment with specificity and minimal side effects. The review also addresses current challenges such as selectivity, biosafety, and stability, and explores future prospects for nanozyme applications in cancer treatment.