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In this study, researchers developed a 3D in vitro model using decellularized Dupuytren’s disease tissue seeded with patient-derived fibroblasts, providing a platform to test antifibrotic therapies like minoxidil and demonstrating more complex drug responses than traditional 2D cultures.

This study developed a novel, 3D-printed dissolving microneedle system for delivering minoxidil to treat hair loss, which showed pH-triggered drug release and enhanced hair regrowth in an alopecia mouse model, offering a potentially sustainable and safe transdermal therapy option.

This study developed and characterized new mouse models of Pemphigus that mimic different forms of the disease, but treatment with Methyl-Prednisolone showed only partial effectiveness.

This study identified novel isoforms of the PADI2 and PADI3 proteins, showing that PADI2β inhibits oligodendrocyte differentiation, possibly by opposing the effect of canonical PADI2, while PADI3β modulates the activity of PADI3α, suggesting new regulatory mechanisms of citrullination in tissue development.

This study observed that PAD type III and trichohyalin are expressed earlier than their deiminated form during the first and second hair cycles in rat hair follicles, indicating a potential additional factor is involved in triggering deimination.

This study found that a novel 3D in vitro culture condition improved stemness markers and proliferation potential in human dermal stem/progenitor cells compared to traditional 2D methods.

In this study, researchers evaluated CS12192, a selective JAK3 inhibitor, in an alopecia areata mouse model and found it reversed hair growth inhibition comparably to baricitinib, with better safety and similar immune-modulating mechanisms.

This study developed a new competitive 5alpha-reductase inhibitor with an IC(50) of 0.84 microM using a novel chemical structure.

This study found that non-balding dermal papilla cells emphasized extracellular matrix organization and reduced inflammation when cultured in 3D or with adipose-derived stem cells, unlike balding cells which maintained inflammatory pathways.

This study found that the addition of SPACE peptide significantly enhanced the penetration of amniotic membrane stem cell metabolites in mice, with only very mild irritation observed.

This study found that Gsdma3 mutations in mice led to thicker skin and longer hair infundibula, possibly by negatively regulating β-catenin expression in the epidermis.

This study found that photobiomodulation via LED light at 630 nm and 810 nm increased proliferation and mineralization in osteoblast-like cells, with comparable effects between the two wavelengths.

This study reported that a three-dimensional hydrogel culture system supports the growth and maintenance of distinct dermal papilla cell types, crucial for skin reconstitution assays in neonatal mice.

P-3074 effectively blocks scalp DHT better than oral finasteride.

TR3 is mainly found in hair follicle stem cells and may be involved in hair loss.

This study found that DPP4 is significantly involved in matrix deposition and fibrosis in human skin fibroblasts, although the exact functions of DPP4 remain unclear.

This study found that a topical vitamin D3 analogue had an anti-proliferative effect on guinea pig skin epidermis.

This study found that using calcipotriene and betamethasone dipropionate cream in a real-world setting significantly improved clinical outcomes and patient quality of life for adults with mild-to-moderate scalp psoriasis, especially among those with higher adherence, demonstrating high treatment satisfaction.

This study indicates that MPZL3 negatively regulates sebaceous gland size in mice by controlling sebocyte proliferation, with implications for disorders like acne and psoriasis.

This study introduced RoPod, a customizable tool for low-stress live imaging of Arabidopsis roots, which improves data reproducibility and provides new insights into plant autophagy by revealing detailed, cell type-specific responses to chemical modulators.

Brodalumab effectively treated a man's severe hand and foot psoriasis.

This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.

In this study, researchers developed a near-infrared-responsive nanoplatform that synergistically enhances chronic wound healing by accelerating mitochondrial restoration and immune modulation, leading to enhanced wound repair and high-quality healing in diabetic rat models.

This study found that in Arabidopsis, the MYB30-EIN3 module plays a role in adapting root hair development to phosphate deficiency, potentially enhancing phosphate uptake from soil.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

This review summarizes recent research and patents on 17β-HSD3, 17β-HSD5, and 3α-HSD3 inhibitors, suggesting their potential in treating androgen-dependent diseases, but reports no new clinical results.

In this study, researchers conducted additional IHC staining on equine skin sections and found that collagen type III primarily labels the extracellular matrix, while anti-PDGFR-antibody staining highlights cells with long-shaped processes mainly arranged around hair follicles.

In this study, the authors reported that AtRXR3, a phosphorus-inducible DUF506 protein, modulates root hair growth under phosphorus stress by interacting with calmodulin and influencing calcium oscillations.

In this comprehensive review, researchers examine the p63 gene's crucial role in skin development and pathology, highlighting its regulation of cell processes and its potential therapeutic implications for disorders like ectodermal dysplasia.

This study developed an in vitro 3D organoid model using dermal papilla spheroids and found that it enhances growth factor expression and extracellular matrix production, which could aid drug screening for hair regeneration.