Development of a 3D In Vitro Model of Dupuytren’s Disease as a Platform for Drug Screening

    Jarmila Knitlová, Adam Eckhardt, Daniel Hadraba … Lucie Bačáková
    Studysummary In this study, researchers developed a 3D in vitro model using decellularized Dupuytren’s disease tissue seeded with patient-derived fibroblasts, providing a platform to test antifibrotic therapies like minoxidil and demonstrating more complex drug responses than traditional 2D cultures.
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    Research cited in this study 2

    1. Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis Biomacromolecules · 2024
    2. Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis Matrix Biology · 2005