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research Development of a 3D In Vitro Model of Dupuytren’s Disease as a Platform for Drug Screening

January 2026 in “Cellular and Molecular Bioengineering”

In this study, researchers developed a 3D in vitro model using decellularized Dupuytren’s disease tissue seeded with patient-derived fibroblasts, providing a platform to test antifibrotic therapies like minoxidil and demonstrating more complex drug responses than traditional 2D cultures.

research Structures of three polycystic kidney disease-like domains fromClostridium histolyticumcollagenases ColG and ColH

18 citations , February 2015 in “Acta Crystallographica Section D: Structural Biology”

This study reports that Ca 2+ binding alters the dynamics and surface properties of PKD-like domains in Clostridium histolyticum collagenases, enhancing their stability and potentially aiding in collagen-targeting vehicle development.

research Stigmata of Liver Disease in a Cirrhotic Patient

January 2019 in “International Journal of Clinical & Medical Images”

This clinical image report discusses a 50-year-old male with ethanol-related chronic liver disease who, despite showing signs of Dupuytren Disease, was asymptomatic and therefore did not receive treatment.

research The skin landscape in diabetes mellitus. Focus on dermocosmetic management

31 citations , May 2013 in “Clinical Cosmetic and Investigational Dermatology”

This review discusses dermocosmetic care for managing DM-related dermatoses, reporting improved skin conditions and quality of life in patients, but highlights limited clinical evidence for these products.