Structures of Three Polycystic Kidney Disease-Like Domains from Clostridium Histolyticum Collagenases ColG and ColH

    February 2015 in “ Acta Crystallographica Section D: Structural Biology ”
    Ryan Bauer, Katarzyna Janowska, Kelly Taylor … J. Sakon
    Studysummary This study reports that Ca 2+ binding alters the dynamics and surface properties of PKD-like domains in Clostridium histolyticum collagenases, enhancing their stability and potentially aiding in collagen-targeting vehicle development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.iucr.org →
    Discuss this study in the Community →

    Research cited in this study 3

    1. Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model Anti-Cancer Drugs · 2013
    2. A Single Injection of the Anabolic Bone Agent, Parathyroid Hormone–Collagen Binding Domain (PTH–CBD), Results in Sustained Increases in Bone Mineral Density for Up to 12 Months in Normal Female Mice Calcified Tissue International · 2012
    3. Treatment for Chemotherapy-Induced Alopecia in Mice Using Parathyroid Hormone Agonists and Antagonists Linked to a Collagen Binding Domain International Journal of Cancer · 2011