Treatment for Chemotherapy-Induced Alopecia in Mice Using Parathyroid Hormone Agonists and Antagonists Linked to a Collagen Binding Domain

The study investigated the use of parathyroid hormone (PTH) agonists and antagonists linked to a collagen binding domain (CBD) to treat chemotherapy-induced alopecia in mice. The PTH-CBD fusion proteins were designed to improve delivery and retention in the skin. In vitro, these proteins bound to collagen and interacted with receptors in cells. In vivo tests on C57BL/6J mice showed that the PTH-CBD agonist promoted faster hair regrowth and repigmentation after chemotherapy, with hair follicles mostly in the anagen phase, indicating reduced chemotherapy-induced damage. The antagonist did not show significant effects compared to the vehicle. The results suggested that PTH-CBD agonists could be a promising treatment for chemotherapy-induced hair loss.