Treatment for Chemotherapy-Induced Alopecia in Mice Using Parathyroid Hormone Agonists and Antagonists Linked to a Collagen Binding Domain

The study investigated the use of parathyroid hormone (PTH) agonists and antagonists linked to a collagen binding domain (CBD) to treat chemotherapy-induced alopecia in C57BL/6J mice. The PTH-CBD fusion proteins were designed to improve hair growth by enhancing delivery and retention in the skin. In vitro, these proteins bound collagen and interacted with PTH receptors. In vivo, mice treated with the PTH-CBD agonist showed more rapid hair regrowth and repigmentation compared to those treated with a vehicle or antagonist, with hair follicles predominantly in the anagen phase. The results suggested that PTH-CBD agonists could potentially mitigate chemotherapy-induced hair follicle damage and serve as a promising therapy for chemotherapy-induced alopecia.