Open and Closed Structure
June 1967
in “
Journal of Cellular Physiology
”
New to Minoxidil? There is a guide in the encyclopedia. Read the guide → Studysummary This study developed an in vitro 3D organoid model using dermal papilla spheroids and found that it enhances growth factor expression and extracellular matrix production, which could aid drug screening for hair regeneration.
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The study developed three-dimensional dermal papilla spheroids (DPS) with or without a silk-gelatin microenvironment, which enhanced DP-specific gene expression and extracellular matrix production compared to monolayer cultures. The DPS model was tested for drug screening using minoxidil, showing increased expression of growth factors and ECM proteins. An in vitro 3D organoid model was also established, incorporating DPS, hair follicle keratinocytes, and stem cells, highlighting the importance of structural features and cell interactions similar to in vivo hair follicles. This model elucidated molecular mechanisms for cell proliferation and hair follicle marker expression, offering insights into hair follicle biology and potential for evaluating new drug efficacy.
