Engineering a 3D Wounded Skin Equivalent to Study Early Inflammatory and Regenerative Responses In Vitro

    August 2025 in “ Frontiers in Bioengineering and Biotechnology ”
    Rima Nuwayhid, Nguyen Ngoc-Huyen, Dmitry Notov … Olga Kurow
    Studysummary This study found that a 3D wound model, the 3DWoundSE, showed improved responsiveness to injury and cytotoxic stimuli compared to an intact 3D skin equivalent, offering a reproducible and ethical alternative to animal models for early wound response assessment in dermatological research and drug development.
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    4. Biofabrication of Human Skin with Its Appendages Advanced Healthcare Materials · 2022
    5. The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier Frontiers in Immunology · 2021
    6. A New 3D Skin Model Containing Autologous Immune Cells Reconstructed by Tissue Engineering Journal of Investigative Dermatology · 2019
    7. Skin Wound Healing in Humans and Mice: Challenges in Translational Research Journal of Dermatological Science · 2017