Engineering a 3D Wounded Skin Equivalent to Study Early Inflammatory and Regenerative Responses In Vitro

August 2025 in “ Frontiers in Bioengineering and Biotechnology ”

Rima Nuwayhid, Nguyen Ngoc-Huyen, Dmitry Notov, Stefan Langer, Olga Kurow

3D wounded skin equivalent wound healing lactate dehydrogenase apoptosis-inducing factor pro-inflammatory cytokines collagen dermatological research drug development therapeutic screening immune cells microfluidic platforms

Studysummary This study found that a 3D wound model, the 3DWoundSE, showed improved responsiveness to injury and cytotoxic stimuli compared to an intact 3D skin equivalent, offering a reproducible and ethical alternative to animal models for early wound response assessment in dermatological research and drug development.

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