Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis

    August 2024 in “ Biomacromolecules ”
    Martina Doubková, Jarmila Knitlová, David Vondrášek … Lucie Bačáková
    Studysummary This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.
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    Research cited in this study 4

    1. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    2. Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis Matrix Biology · 2005
    3. Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil Journal of Biological Chemistry · 1987
    4. Effects of Minoxidil on Cultured Human Skin Fibroblasts Dermatology · 1987