Recyclable Polymerizable Deep Eutectic Solvent-Based Three-Dimensional-Printed Dissolving Microneedles with pH-Responsive Delivery of ZIF-8-Loaded Minoxidil for Hair Loss Therapy

March 2026 in “ Figshare ”

Nail Aminov, Huan Liu (281351), Decheng Meng, Liran Zhu, Xiaohan Guo, Cong Li (115171), Xiaoqing Ye, Huanjun Li (5374703)

minoxidil dissolving microneedles ZIF-8 nanoparticles transdermal delivery pH-responsive cyclophosphamide-induced alopecia hair follicle density alopecia deep eutectic solvent MXD MN PDES

TLDR The new microneedle system effectively delivers minoxidil for hair regrowth with minimal side effects.

The study presents a novel three-dimensional-printed dissolving microneedle (MN) system designed for improved transdermal delivery of minoxidil (MXD) to treat hair loss. This system features a recyclable polymerizable deep eutectic solvent (PDES) base and pH-responsive tips loaded with MXD-encapsulated ZIF-8 nanoparticles. The MNs demonstrated effective skin penetration, mechanical integrity, and minimal cytotoxicity. In vitro and in vivo tests, including a cyclophosphamide-induced alopecia mouse model, showed pH-triggered drug release and significant hair regrowth, with enhanced hair follicle density and minimal systemic toxicity. This innovative MN platform offers a promising and sustainable approach for targeted hair loss therapy.

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research Recyclable Polymerizable Deep Eutectic Solvent-Based 3D-Printed Dissolving Microneedles with pH-Responsive Delivery of ZIF-8-Loaded Minoxidil for Hair Loss Therapy

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Recyclable Polymerizable Deep Eutectic Solvent-Based Three-Dimensional-Printed Dissolving Microneedles with pH-Responsive Delivery of ZIF-8-Loaded Minoxidil for Hair Loss Therapy

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