Recyclable Polymerizable Deep Eutectic Solvent-Based Three-Dimensional-Printed Dissolving Microneedles with pH-Responsive Delivery of ZIF-8-Loaded Minoxidil for Hair Loss Therapy
March 2026
in “
Figshare
”
New to Minoxidil? There is a guide in the encyclopedia. Read the guide → Studysummary This study developed a novel, 3D-printed dissolving microneedle system for delivering minoxidil to treat hair loss, which showed pH-triggered drug release and enhanced hair regrowth in an alopecia mouse model, offering a potentially sustainable and safe transdermal therapy option. Our plain-language summary of this paper — not a Tressless recommendation.
The study presents a novel three-dimensional-printed dissolving microneedle (MN) system designed for improved transdermal delivery of minoxidil (MXD) to treat hair loss. This system features a recyclable polymerizable deep eutectic solvent (PDES) base and pH-responsive tips loaded with MXD-encapsulated ZIF-8 nanoparticles. The MNs demonstrated effective skin penetration, mechanical integrity, and minimal cytotoxicity. In vitro and in vivo tests, including a cyclophosphamide-induced alopecia mouse model, showed pH-triggered drug release and significant hair regrowth, with enhanced hair follicle density and minimal systemic toxicity. This innovative MN platform offers a promising and sustainable approach for targeted hair loss therapy.
